Physical and Applied Pharmaceutics

About Physical & Applied Pharmaceutics

The disciplines of physical and applied pharmaceutics encompass the scientific foundations of pharmaceutical product quality including topics in physical, analytical and biophysical chemistries and material sciences.

Graduates of this program are expected to understand how to apply fundamental scientific principles and research techniques to solve the problems encountered in the design and development of pharmaceutical products of the highest quality.

Faculty members in the Division of Pharmaceutics and Translational Therapeutics are engaged in applied and fundamental research aimed at improving and re-engineering the pharmaceutical product and process design and development.

Faculty Research in Physical & Applied Pharmaceutics

Dr. Douglas Flanagan's research group conducts research in the areas of physical pharmacy and drug delivery. He has directed doctoral students on projects involving biodegradable polymeric delivery systems, liposomal formulations, dissolution phenomena and membrane permeability. He currently has students working on solid-state desolvation kinetics, mucoadhesive polymeric delivery systems and drug/polymer co-precipitates.

Research projects in the laboratory of Dr. Lee Kirsch are based on recurring problems encountered in industrial drug product design, manufacturing and/or delivery including the kinetics and mechanisms of chemical and physical instability of peptide/protein drugs and dispersed/colloidal drug formulations, and quality assurance issues in pharmaceutical package integrity and parenteral manufacturing technologies. Although these research projects arise from pragmatic issues, the approaches used in Dr. Kirsch’s laboratory are typically aimed at fundamental and mechanistic understandings of the underlying physical chemical phenomena.

Members of Dr. Dale Eric Wurster's research group work on projects which involve the study of physical forces of interaction. These projects are quite diverse, and involve the study of adsorptive processes occurring in solution, adsorbent surface characterization, water vapor sorption by polymers, chemical catalysis in the micellar environment, and the physics of powder compaction. Calorimetric techniques are widely employed for analyzing the aforementioned phenomena.

Dr. Lewis Stevens' research interests emphasize the influential role of mechanical properties in broad application to biochemistry, drug delivery and physical pharmacy. Associated with our approach is the development of novel spectroscopic solutions that advance material characterization in (1) nanoparticle elasticity, (2) intelligent hydrogel formation, (3) solid-state polymorphism and (4) biotherapeutic dynamics/aggregation.