Clinical Pharmaceutical Sciences Research
Dr. Gary Milavetz's research interests include the pharmacotherapeutics of respiratory medications. He has numerous original research publications on the pharmacokinetics, pharmacodynamics and clinical efficacy of medications used to treat respiratory disease.
Dr. Nicole Brogden is both a clinical pharmacist and pharmaceutical scientist, and her overall research interests encompass the development of novel drug delivery systems. More specifically, her research program is focused on cutaneous delivery methods (topical and transdermal delivery) and exploring various means of enhancing the percutaneous delivery of otherwise skin-impermeable compounds. Dr. Brogden’s group is exploring various microneedle delivery techniques for local and systemic delivery of compounds that would present distinct advantages when delivered via the skin, including novel plant compounds. Using a combination of impedance spectroscopy, transepidermal water loss, and drug diffusion studies, the laboratory is studying the effect of microneedles on skin permeation and penetration, as well as age-related effects in healing and barrier restoration. Current disease states of interest within the group include pain control, alcohol abuse, osteoarthritis, and local skin lesions.
After receiving her MD from Taishan Medical College and MS in Clinical Pharmacology from Fudan University, Dr. An joined Ruijin Hospital for 2 years as a clinical pharmacist and research scientist. Then she pursued a further study and got her PhD degree in Pharmaceutical Sciences from SUNY at Buffalo. Her graduate research focused on the role of transporter on the pharmacokinetics (PK) and pharmacodynamics (PD) of anticancer agent. Her research was further expanded after she joined the R&D group of Abbott, where she gained extensive hands on experience in clinical drug development, PK/PD modeling and simulation. Prior to joining University of Iowa, Dr. An has worked at University of Florida as an Assistant Professor for one and half years. Dr. An's research interests include building mechanism-based PK/PD modeling of small molecules (such as tysosine kinase inhibitors) and large molecules (such as Epo); understanding the mechanisms of poor brain penetration of small molecule tyrosine kinase inhibitors and offering novel approaches to overcome it; evaluating the transporter- and enzyme-based herbal-drug interactions.