Dale Eric Wurster

Dale Eric Wurster

  • Professor, Department of Pharmaceutical Sciences and Experimental Therapeutics / Division of Pharmaceutics and Translational Therapeutics

Research Narrative

Dr. Wurster's research interests include the physics of tablet compression, adsorption and desorption thermodynamics, solution calorimetry, analytical applications of FT-IR, surface characterization by XPS, and micellar catalysis.

Curriculum vitae

Education
1974 BS (Chemistry), University of Wisconsin
1979 PhD (Physical Pharmacy), Purdue

Professional Experience
July 1996-Present: Professor, University of Iowa College of Pharmacy (see PhD in Pharmaceutics page)
Jan. 2007-Present: Professor, Interdisciplinary Graduate Program in Human Toxicology
July 2015-Present: Professor, Graduate Program in Informatics
Aug. 2009-June 2015: Senior Associate Dean for Academic Affairs, UI Graduate College
Jan. 2002-Aug. 2009 Associate Dean for Academic Affairs, UI Graduate College
July 2006-June 2012: Professor, UI Department of Chemical and Biochemical Engineering
Jan. 2000-Dec. 2001: Chair, Division of Pharmaceutics, UI College of Pharmacy
July 1987-June 1996: Associate Professor, UI College of Pharmacy
Dec. 1982-June 1987: Assistant Professor, UI College of Pharmacy
March 1979-Nov. 1982 Assistant Professor, University of North Carolina

Research Interests
Dr. Wurster's research interests include the physics of tablet compression, adsorption and desorption thermodynamics, solution calorimetry, analytical applications of FT-IR, surface characterization by XPS, and micellar catalysis.

Recent Publications
Büyüktimkin, Tuba and Wurster DE. "The Influence of the Adsorption of Metoclopramide on the Surface Ionization of Fumed Silica," International Journal of Pharmaceutics, 478, 164-171 (2015).

Büyüktimkin, Tuba and Wurster DE. "Quantitative Structure-Activity Relationship Analysis of the Effect of Metoclopramide and Related Compounds on the Surface Ionization of Fumed Silica," J. Pharm. Sci., 104(8), 2566-2573 (2015).

Wurster DE and Buckner IS. Characterizing compaction-induced thermodynamic changes in a common pharmaceutical excipient. J Pharm Sci. 101(8): 2960-7, 2012.

Qian KK, Wurster DE, Bogner RH. Spontaneous crystalline-to-amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 3: effect of moisture. Pharm Res. 29(10): 2698-709, 2012.

 Dogan M, Dogan AU, Aburub A, Botha A, Wurster DE. Quantitative mineralogical properties (morphology-chemistry-structure) of pharmaceutical grade kaolinites and recommendations to regulatory agencies. Microsc Microanal. 18(1): 143-51, 2012.

 Qiang D, Wurster DE. Specific and non-specific interactions of procaine with activated carbon surfaces. J Colloid Interface Sci. 358(2): 541-6, 2011.

 Buckner IS, Wurster DE and Aburub A. Interpreting deformation behavior in pharmaceutical materials using multiple consolidation models and compaction energetics. Pharmaceutical Development and Technology, 15(5): 492-499, 2010.

Wurster DE and Werawatganone P. Influence of the Polymer-Micelle Interaction on Micelle-Substrate Binding. Journal of Pharmaceutical Sciences, 99(3): 1440-1451, 2010.

Buckner IS, Friedman RA and Wurster DE. Using Compression Calorimetry to Characterize Powder Compaction Behavior of Pharmaceutical Materials. Journal of Pharmaceutical Sciences, 99(2): 861-870, 2010.

Junyaprasert VB, Boonme P, Wurster DE, et al. Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic and hydrophilic local anesthetics. Drug Delivery, 15(5): 323-330, 2008.

Bhattacharjya S and Wurster DE. Investigation of the drug release and surface morphological properties of film-coated pellets, and physical, thermal and mechanical properties of free films as a function of various curing conditions. AAPS PharmSciTech, 9(2): 449-457, 2008.

Wurster DE, Flanagan DR., and Bhattacharjya S. Effect of Curing on Water Diffusivities in Acrylate Free Films as Measured via a Sorption Technique. AAPS PharmSciTech, 8(3): E71, 2007. (http://www.aapspharmscitech.org/).

Werawatganone P and Wurster DE."Determination of the Hydrolysis Kinetics of alpha-Naphthyl Acetate in Micellar Systems and the Effect of HPMC (Catalyst Present)," J. Pharm. Sci. 96(2): 448-458, 2007.

Dogan M, Dogan AU, Yesilyurt FI, Alaygut D, Buckner I, Wurster DE. Baseline Studies of the Clay Minerals Society Special Clays:  Specific Surface Area by Brunauer, Emmett, and Teller (BET) Method. Clays and Clay Minerals, 55(5): 534-541, 2007.

 Likitlersuang S, Wurster DE, Chen Y. The effect of binary mixture composition and magnesium stearate concentration on the Hiestand Tableting Indices and other related mechanical properties. Pharm Dev Technol. 12(5): 533-41, 2007.

Wurster DE and Aburub A. The Effects of Surface Lactone Hydrolysis and Temperature on the Specific and Non-Specific Interactions between Phenobarbital and Activated Carbon Surfaces. J. Pharm. Sci. 95(7): 1540-1548, 2006.

Dogan AU, Dogan M, Onal M, Sarikaya Y, Aburub A, and Wurster DE. Baseline Studies of the Clay Minerals Society Source Clays: Specific Surface Area by Brunauer, Emmett, and Teller (BET) Method. Clays and Clay Minerals, 54(1): 62-66, 2006.

Aburub A and Wurster DE. Phenobarbital Interations with Derivatized Activated Carbon Surfaces. Journal of Colloid and Interface Science, 296(1): 79-85, 2006.

Wurster DE and Bandopadhyay R. The Use of Isoperibol Calorimetry for the Study of Age-related Changes in Glucose Uptake by Erythrocytes. Journal of Thermal Analysis and Calorimetry, 79: 737-740, 2005.

Wurster DE, Likitlersuang S, and Chen Y. The Influence of Magnesium Stearate on the Hiestand Tableting Indices and Other Related Mechanical Properties of Maltodextrins. Pharmaceutical Development and Technology, 10(4): 461-466, 2005.

Li LC, Zhu L, Song J, Deng J-S, Bandopadhyay Ri, and Wurster DE. Effect of Solid State Transition on the Physical Stability of Suspensions Containing Bupivacaine Lipid Microparticles. Pharmaceutical Development and Technology, 10(2): 309-318, 2005.

Vander Kamp KA, Qiang D, Aburub A, and Wurster DE. Modified Langmuir-like Model for Modeling the Adsorption from Aqueous Solutions by Activated Carbons. Langmuir, 21: 217-224, 2005.

Dogan AU, Dogan M, Chan D, and Wurster DE. Bassanite from Salvadora Persica: a New Evaporitic Biomineral. Journal of Carbonates and Evaporites, 20(1): 2-7, 2005.

Keller, JC, Wurster DE, and Barkan SH. The Development and Evolution of Interdisciplinary Graduate Programs at The University of Iowa. Journal for Higher Education Strategists, 2: 99-107, 2004.

Van Tonder EC, Maleka, Tshoane SP, Liebenberg W, Song M, Wurster DE, de Villiers MM. Preparation and Physicochemical Properties of Niclosamide Anhydrate and Two Monohydrates. Int. J. Pharmaceut, 269: 417-432, 2004.

Wurster DE, Alkhamis KA, and Matheson LE. Prediction of the Adsorption of Diazepam by Activated Carbon in Aqueous Media. J. Pharm. Sci., 92(10): 2008-2015, 2003.

Alkhamis KA, and Wurster DE. Study of Multiple Component Adsorption on the Surface of Activated Carbon Using a Model System of Benzyl Alcohol and Phenobarbital. Pharm. Dev. Technol., 8(2): 127-133, 2003.

Alkhamis KA, and Wurster DE. Prediction of Adsorption from Multicomponent Solutions by Activated Carbon Using Single- Solute Parameters. Part II- Proposed Equation. AAPS PharmSciTech, 3(3): E23, 2002. (http://pharmscitech.com/).

Luner PE, Kirsch LE, Majuru S, Oh E, Joshi AB, Wurster DE and Redmon, Martin P. Preformulation Studies on the S- Isomer of Oxybutynin Hydrochloride, An Improved Chemical Entity (ICETM). Drug Dev. Ind. Pharm., 27: 321-329, 2001.

Kirsch L, Zhang S, Muangsiri W, Redmon M, Luner P and Wurster DE. Development of a Lyophilized Formulation for (R,R)- Formoterol (L)-Tartrate. Drug Dev. Ind. Pharm, 27: 89-96, 2001.

Junyaprasert, VB, Mitrevej A, Sinchaipanid N, Boonme P and Wurster DE. Effect of Process Variables on the Microencapsulation of Vitamin A Palmitate by Gelatin-Acacia Coacervation. Drug Dev. Ind. Pharm., 27: 551-556, 2001.

Wurster DE, Alkhamis KA, and Matheson LE. Prediction of Adsorption from Multicomponent Solutions by Activated Carbon Using Single-Solute Parameters. AAPS PharmSciTech, 1(3): E25, 2000.  (http://pharmscitech.com/).

Amidon GE, Augsburger LL, Brittain HG, Byrn SR, Fox CD, Peck GE, and Wurster DE. Proposed New General Test Chapter: "Tablet Breaking Force," Pharmacop. Forum, 26: 513-515, 2000.