Maureen D Donovan

Maureen D Donovan

, PhD
  • Associate Dean for Undergraduate Education, Office of the Dean
  • Professor, Department of Pharmaceutical Sciences and Experimental Therapeutics / Division of Pharmaceutics and Translational Therapeutics

Research Narrative

Dr. Donovan's research interests include novel drug delivery systems in mucosal drug delivery especially via the nasal, gastrointestinal and vaginal epithelia; and mechanisms of drug absorption and disposition.

Curriculum vitae

Education
1989 PhD (Pharmaceutics), The University of Michigan
1983 BS (Pharmacy), University of Minnesota

Professional Experience
2008-present, Professor; Division of Pharmaceutics, College of Pharmacy, The University of Iowa
1996-2008, Associate Professor; Division of Pharmaceutics, College of Pharmacy, The University of Iowa
1991, Visiting Scholar; SmithKline Beecham Pharmaceuticals
1989-1996, Assistant Professor; Division of Pharmaceutics, College of Pharmacy, The University of Iowa

Research Interests
Dr. Donovan's research interests include novel drug delivery systems in mucosal drug delivery especially via the nasal, gastrointestinal and vaginal epithelia; and mechanisms of drug absorption and disposition.

Recent Publications
Lack WD, Fredricks D, Petersen E, Donovan MD, George M, Nepola J, Smucker J and Fermino JE.  The Effect of Low Dose Aspirin on Bone Healing in a Rabbit Ulna Osteotomy Model. J  Bone Joint Surg, 95(6), 488-96, 2013, [doi: 10.2106/JBJS.L.00462].

Zhang H, Lin C-W and Donovan MD.  Correlation between Nasal Membrane Permeability and Nasal Absorption Rate. AAPS PharmSciTech  14(1), 60-63, 2013, [doi:10.1208/s12249-012-9884-2].

Zhang H, Prisinzano TE and Donovan MD. Permeation and Metabolism of Cocaine in the Nasal Mucosa.  Eur J Drug Metab Pharmacokinetics 37(4), 255-262, 2012, [doi:10.1007/s13318-012-0085-x].

Zhang H, Schmidt M, Murry DJ and Donovan MD. Permeation and Systemic Absorption of R- and S- Baclofen across the Nasal Mucosa. J. Pharm. Sci.,100. 2717-2723, 2011, [doi:10.1002/jps.22499; PMIC 21283988].

Abbas AO, Donovan MD and Salem AK. Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery. Journal of Pharmaceutical Sciences, Vol 97 Iss 7 pp 2448-2461, 2008.

Foo MY, Cheng YS and Su WC, et al. The influence of spray properties on intranasal deposition. Journal of Aerosol Medicine- Deposition Clearance and Effects In the Lung, Vol 20 Iss 4 pp 495-508, 2007.

Chemuturi NV and Donovan MD. Role of organic cation transporters in dopamine uptake across olfactory and nasal respiratory tissues. Molecular Pharmaceutics Vol 4 Iss 6 pp 936-942, 2007.

Donovan MD. Graduate Education in Colleges of Pharmacy in AACP Deans Manual, P. Chase, B. Hayes, V. Yanchik (Eds). 2007.

Donovan MD. Gender Equity in Faculty Hiring and Retention in AACP Deans Manual, P. Chase, B. Hayes, V. Yanchik (Eds). 2007.

Shah AJ and Donovan MD. Formulating Gels for Decreased Mucociliary Transport Using Rheologic Properties: Polyacrylic Acids. AAPS PharmSciTech, Article 33, 2007. (www. aapspharmscitech.org) doi: 10.1208/pt0802033

Shah AJ and Donovan MD. Rheological Characterization of Bioadhesive Polysaccharide Polymers with Reduced Mucociliary Clearance for Intranasal Delivery. AAPS PharmSciTech, 8(2):Article 32, 2007.
(www. aapspharmscitech.org) doi: 10.1208/pt0802032

Donovan MD. Nose to Brain Drug Delivery: An Optimistic Pessimist’s Analysis. In Respiratory Drug Delivery 2006. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International Publishers, River Grove IL. 2006, p. 239-248.

Chemuturi NV, Haraldsson JE, Prisinzano TP, and Donovan MD. Role of Dopamine Transporter (DAT) in Dopamine Transport Across the Nasal Mucosa. Life Sci 79, 1391-1398, 2006.

Chemuturi NV and Donovan MD. Metabolism of Dopamine Hydrochloride by the Nasal Mucosa. J Pharm Sci 95, 2507-2515, 2006 (doi:10.1002/jps.20724).

Donovan MD. Gender and Racial Differences in Pharmacologic Response. Effect of Route of Administration and Drug Delivery System on Pharmacokinetics. J Womens Health. 14: 30-37, 2005.

Kandimalla K and Donovan MD. The Role of Drug Efflux in Limiting Nose to Brain Transport: Chlorpheramine and Chlorcyclizine Transport. J Pharm Sci 94: 613-624, 2005.

Kandimalla K and Donovan MD. Localization and Differential Activity of P-glycoprotein in the Bovine Olfactory and Nasal Respiratory Mucosae. Pharm Res 22: 1121-1128, 2005.

Kandimalla K and Donovan MD. Transport of Hydroxzine and Triprolidine Across Bovine Olfactory Mucosa: Role of Passive Diffusion in Direct Nose-to-Brain Uptake of Small Molecules. Int J Pharm 302: 133-144, 2005.

Sinn PL, McCray PB, Donovan MD, and Shah AJ. Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors. Am J Resp Cell Mol Biol 32: 404-410, 2005.

Chemuturi NV, Hayden P, Klausner M, and Donovan MD. Comparison of human tracheal/broncial epithelial cell cultures (EpiAirway) and bovine nasal respiratory explants for nasal drug transport studies. J Pharm Sci 94: 1976-1985, 2005.

Khanvilkar K, Donovan MD, and Flanagan DR. Drug transfer through mucus. Adv Drug Delivery Rev 48:173-193, 2001.