Zhendong Jin

Zhendong Jin

  • Associate Professor, Department of Pharmaceutical Sciences and Experimental Therapeutics / Division of Medicinal and Natural Products Chemistry

Research Narrative

The main emphasis of Dr. Jin’s research is the total synthesis of various biologically active natural products and structural analogues, the discovery and development of new synthetic methods with particular interest in asymmetric reactions, and synthesis of novel anticancer agents.

Curriculum vitae

Education
PhD Chemistry, Purdue University (under the guidance of Prof. Philip L. Fuchs), 1995

Professional Experience
NIH Postdoctoral Fellow
1996-1997, The Scripps Research Institute, (w/ Prof. K. C. Nicolaou)
1997-2003, University of Iowa, College of Pharmacy, Assistant Professor
2003-present, University of Iowa, College of Pharmacy, Associate Professor

Research
The main emphasis of my research is the total synthesis of various biologically active natural products and structural analogues, the discovery and development of new synthetic methods with particular interest in asymmetric reactions, and synthesis of small libraries with the aim of anticancer drug discovery.

Representative Publications
Jin, Z., Shah, A. K. Encyclopaedia of Reagents for Organic Synthesis. John Wiley & Sons, Ltd. in press.

Garcia-Prieto C, Riaz Ahmed KB, Chen Z, Zhou Y, Hammoudi N, Kang Y, Lou C, Mei Y, Jin Z, Huang P. 2013. Effective Killing of Leukemia Cells by the Natural Product OSW-1 through Disruption of Cellular Calcium Homeostasis. J. Biol. Chem. 288, 3240.

Chen L, Riaz Ahmed KB, Huang P, Jin Z.  2013. Design, Synthesis and Biological Evaluation of Truncated Superstolide A. Angewandte Chemie Int. Ed. 52, 3446.

Chen, L., Hua, Z., Li, G., Jin, Z. 2011. Controlling the Facial Selectivity of Asymmetric [4+2] Cycloadditions: A Concise Synthesis of the cis-Decalin Core Structure of Superstolides A and B, Org. Lett. 13, 3580.

Jin, Z., Zhang, Z. 2010. Cyanotrimethylsilane. Encyclopaedia of Reagents for Organic Synthesis. John Wiley & Sons, Ltd.

Kang, Y., Lou, C., Ahmed, K. B. R., Huang, P., Jin, Z. 2009. Synthesis of a Biotinylated-OSW-1. Bioorg. Med. Chem. Lett. 19, 5166.

Hua, Z., Chen, L., Jin, Z. 2009. Asymmetric [4+2] Cycloadditions Employing 1,3-Dienes Derived from Chiral 4-Hydroxy-2-cyclohexenone. Tetrahedron Lett. 50, 6621.

Lou, C., Jin, Z. 2005. Ethoxyacetylene. Encyclopaedia of Reagents for Organic Synthesis. John Wiley & Sons, Ltd.

Zhou, Y., Garcia-Prieto, C., Carney, D., Xu, R., Pelicano, H., Kang, Y., Yu, W., Lou, C., Kondo, S., Liu, J., Harris, D., Estrov, Z., Keating, M. J., Jin, Z., Huang, P. 2005. OSW-1: A Natural Compound with Potent Anticancer Activity and Novel Mechanism of Action. Journal of the National Cancer Institute, 97, 1781.

Hua, Z., Yu, W., Su, M., Jin, Z. 2005. Synthetic Studies toward the Construction of the cis-Decalin Portion of Superstolides A and B. Application of a Sequential Double Michael Reaction and an Anionic Oxy-Cope Rearrangement. Org. Lett. 7, 1939.

Gao, X., Yu, W., Mei, Yan, Jin, Z. 2004. Heck Reaction with an Acyl Synthon: New Coupling Reaction between α-Halo Vinyl Ether and Alkene. Tetrahedron Lett. 45, 8169.

Hua, Z., Yu, W., Jin, Z. 2004. An Improved Procedure for the Oxidative Cleavage of Olefins by OsO4-NaIO4. Org. Lett. 6, 3217.

Kang, Y., Mei, Y., Du, Y., Jin, Z. 2003. Total Syntheses of the Highly Potent anti-HIV Natural Product Daurichromenic Acid and its Two Novel Chromene Derivatives, Rhododaurichromanic Acids A and B. Org. Lett. 5, 4481.

Yu, W., Jin, Z. 2002. Total Synthesis of An Antitumor Natural Product OSW-1. J. Am. Chem. Soc. 124, 6576.

Su, M., Kang, Y., Yu, W., Hua, Z., Jin, Z. 2002. Negishi Coupling between a-Alkyl(aryl)thio Vinyl Zinc Chloride and α-Bromo Vinyl Ether: a Convergent Synthesis of 2-Alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes. Org. Lett. 4, 691.

Su, M., Yu, W., Jin, Z. 2001. A Highly Stereoselective Synthesis of a-Halo Vinyl Sulfides and Their Applications in Organic Synthesis. Tetrahedron Lett. 42, 3771.

Yu, W., Zhang, Y., Jin. Z. 2001. Synthetic Studies of Antitumor Marine Natural Products Superstolides A and B. Construction of C20-C26 Fragment of Superstolide A, Org. Lett. 3, 1447.

Yu, W., Jin, Z. 2001. A New Strategy for the Stereoselective Introduction of Steroid Side Chain via α-Alkoxy Vinyl Cuprates: Total Synthesis of a Highly Potent Antitumor Natural Product OSW-1, J. Am. Chem. Soc. 123, 3369.

Yu, W., Jin, Z. 2001. A Facile Generation of Enolates from Silyl Enol Ethers by Potassium Ethoxide. Tetrahedron Lett. 42, 369.

Yu, W., Jin, Z. 2000. A Facile Stereospecific Synthesis of α-Halo Vinyl Ethers and Their Applications in Organic Synthesis. J. Am. Chem. Soc. 122, 9840.

Yu, W., Su, M., Gao, X., Yang, Z., Jin, Z. 2000. A Facile Chemoselective Deprotection of p-Methoxybenzyl Group. Tetrahedron Lett. 41, 4015.

Yu, W., Su, M., Jin, Z. 1999, A Highly Selective Synthesis of (Z)-α,β-Unsaturated Ketones. Tetrahedron Lett. 40, 6725.

Patent Filed
Total synthesis of OSW-1, Zhendong Jin, Wensheng Yu, Provisional Patent Application No.60/310,709.

Total Synthesis of the Highly Potent anti-HIV Natural Product Daurichromenic Acid along with Its Two Chromane Derivatives, Rhododaurichromanic Acids A and B, Ying Kang, Yan Mei, Zhendong Jin.

The Use of Orsaponin [3ß,16ß,17α-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxy-benzoyl-ß-D-xylopyranosyl)-(13)-(2-O-acetyl-α-L-arabinopyranoside)] and Its Derivatives for Cancer Therapeutics, Peng Huang, Michael J. Keating, Zhendong Jin.