Division of Pharmaceutics, Department of Chemical and Biochemical Engineering
Division of Pharmaceutics
College of Pharmacy, University of Iowa
115 S. Grand Avenue, S215 PHAR
Iowa City, IA 52242
Phone: 319 335-8830
FAX: 319 335-9349
1998 BS (Chemical Engineering); University of Massachusetts at Amherst
2004 PhD (Chemical and Biomolecular Engineering); The Johns Hopkins University
2004-2006 Postdoctoral Fellowship (Biomedical Engineering); Harvard University
2006-present Assistant Professor, Colleges of Pharmacy and Engineering, University of Iowa
2004-2006 Postdoctoral Fellow, Division of Engineering and Applied Sciences, Harvard University
1998-2003 National Science Foundation Graduate Student Fellow, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Research in Dr. Jennifer Fiegel's laboratory focuses on the development of novel drug delivery systems for diseases of the lung, with special emphasis on infectious and inflammatory diseases. Through experimental studies and mathematical modeling, the laboratory designs medical aerosols with an improved ability to target the delivery of therapeutics within the lungs and explores the complex physical interactions between these delivery systems and various cells and fluids native to the lungs. The group is also investigating new ways to suppress the transmission of airborne pathogens via local variations in the lung lining fluid.
Farnoud A, Fiegel J. Low concentrations of negatively charged sub-micron particles alter the microstructure of DPPC at the air-water interface. Colloid. Surface. A. 415(5): 320-327, 2012.
Oldham ED, Xie W, Farnoud AM, Fiegel J, Lehmler HJ. Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutanesulfonate. J Phys Chem B. 23;116(33):9999-10007, 2012.
Sommerfeld Ross S, Fiegel J. Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms. Int J Antimicrob Agents. 40(2):177-81, 2012.
Sommerfeld Ross S, Reinhardt JM, Fiegel J. Enhanced analysis of bacteria susceptibility in connected biofilms. J Microbiol Methods. 90(1):9-14, 2012.
Ross S, Thomas E, Stohs B, Fiegel J. Treating lung biofilm infections: Dispersion and eradication via dry powder aerosols. Respir. Drug Deliv. 3: 813-817, 2010.
Patton JS, Brain JD, Davies LA, Fiegel J, Gumbleton M, Kim KJ, Sakagami M, Vanbever R, Ehrhardt C. The Particle has Landed-Characterizing the Fate of Inhaled Pharmaceuticals. Journal of Aerosol Medicine and Pulmonary Drug Delivery. Vol 23 pp S71-S87, 2010.
Fiegel J, Garcia-Contreras L and Thomas M, et al. Preparation and in Vivo evaluation of a dry powder for inhalation of capreomycin. Pharmaceutical Research Vol 25 Iss 4 pp 805-811, 2008.
Garcia-Contreras L, Fiegel J, Telko MJ, Elbert K, Hawi A, Thomas M, VerBerkmoes J, Germishuizen WA, Fourie PB, Hickey AJ, Edwards D. Inhaled large porous particles of capreomycin for the treatment of tuberculosis in a guinea pig model. Antimicrob. Agents Chemother. 51(8): 2830-2836, 2007.
Watanabe W, Thomas M, Clarke R, Klibanov A, Langer R, Fuller G, Griel L, Fiegel J , Edwards D. Why inhaling salt water changes what we exhale. J. Colloid Interface Sci. 307(1): 71-78, 2007.
Fiegel J, Clarke R, Edwards D. Airborne infectious disease and the suppression of exhaled aerosols [review]. Drug Discovery Today. 11(1-2):51-57, 2006.
D.A. Edwards, Fiegel J, DeHaan W, Brande M, Man J, Clarke R. Novel inhalants for control and protection against airborne infections [review]. Respiratory Drug Delivery. 1: 41-48, 2006.
Fiegel J, Jin F, Hanes J, Stebe K. Wetting of a particle in a thin film. J. Colloid Interface Sci. 291(2):507-514, 2005.
Fiegel J, Fu J, Hanes J. Poly(ether-anhydride) microparticle aerosolization improved by controlling particle surface properties. J. Control. Release. 96(3):411-423, 2004.
Fu J, Fiegel J, Hanes J. Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for pulmonary drug delivery. Macromolecules. 37(19): 7174-7180, 2004.
Fiegel J, Ehrhardt C, Schaefer UF, Lehr CM, Hanes J. Large porous particle impingement on lung epithelial cell monolayers: Toward improved particle characterization in the lung. Pharm. Res. 20(5):788-796, 2003.
Hanes J, Dawson M, Har-el Y, Suh J, and Fiegel J. Gene Therapy in the Lung. In: A. J. Hickey (ed.) Pharmaceutical Inhalation Aerosol Technology, 2nd edition. Vol. 134. New York: Marcel Dekker Inc. 2003.
Fu J, Fiegel J, Krauland E, Hanes J. New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials. 23(22):4425-4433, 2002.
Ehrhardt C, Fiegel J, Fuchs S, Abu-Dahab R, Schaefer UF, Hanes J, Lehr CM. Drug absorption by the respiratory mucosa – Cell culture models and particulate drug carriers. J. Aerosol Med. 15(2):131-139, 2002.
Ehrhardt C, Kneuer C, Fiegel J, Hanes J, Schaefer UF, Kim KJ, Lehr CM. Influence of apical fluid volume on the development of functional cellular junctions in the human bronchial epithelial cell line 16HBE14o-: implications for the use as an in vitro model for drug absorption. Cell & Tissue Research. 308:391-400, 2002.