Division of Pharmaceutics
College of Pharmacy, University of Iowa
115 S. Grand Avenue, S228 PHAR
Iowa City, IA 52242
Phone: 319 335-8810
FAX: 319 335-9349
1998 BSc (1st Class Hons Applied Chemistry); Aston University, U.K.
2002 PhD (Pharmaceutical Sciences); University of Nottingham, U.K.
2002-2004 Postdoctoral Fellowship (Medicine); The Johns Hopkins University
2009-present Associate Professor, College of Pharmacy, University of Iowa
2004-2009 Assistant Professor, College of Pharmacy, University of Iowa
2002-2004 Postdoctoral Fellow, Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University
2001-2002 Scientific Consultant, Regentec Ltd, Nottingham, U.K.
1998-2001 Scientist, Pharmaceutical Profiles, Nottingham, U.K.
Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of vaccines that stimulate potent antigen-specific immune responses. Dr Salem's laboratory applies microfabrication techniques to develop novel drug and gene delivery devices and to optimize control over polymer-cell interactions. The group is currently exploring the synergistic application of polymer particle technology, CpG oligonucleotides, adenoviruses and heat shock protein therapy for generating sustained stronger immune responses against tumors.
Geary SM Lemke CD Lubaroff DM and Salem AK. Tumor immunotherapy using adenovirus vaccines in combination with intramoral doses of CpG ODN. Cancer Immunology. Immunotherapy. 2011
Lemke CD Graham JB Geary SM Zamba G Lubaroff DM and Salem AK. Chitosan is a surprising negative modulator of cytotoxic CD8+ T cell responses elicited by adenovirus cancer vaccines.Molecular Pharmaceutics 2011
Kim N Jiang D Jacobi A Lennox KA Rose S Behlke MA and Salem AK. Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA.International Journal of Pharmaceutics. 2011
Santillan DA Rai KK Santillan MK Krishnamachari Y Hunter S and Salem AK. Efficacy of Polymeric Encapsulated C5a peptidase-based Group B Streptococci Vaccines in a Murine Model.American Journal of Obstetrics & Gynecology 2011
Lemke CD Graham JB Lubaroff DM and Salem AK. Development of an MHC class I Ld-restricted PSA peptide-loaded tetramer for detection of PSA-specific CD8+ T cells in the mouse. Prostate Cancer and Prostatic Diseases, 2011.
Intra J Zhang XQ Williams RL Zhu X Sandler AD and Salem AK. Immunostimulatory sutures that treat local disease recurrence following primary tumor resection. Biomedical Materials, 2011.
Geary SM Lemke CD Krishnamachari Y and Salem AK. New nanobiotechnological strategies for the development of vectors for cancer vaccines. Pharmaceutical Biotechnology 2nd Edition. Wiley-Blackwell, 2011.
Kuruvilla DJ and Salem AK. Nanotechnology and nanomedicine in diabetes: an overview. Nanotechnology and nanomedicine in diabetes. Science Publishers, 2011.
Hong L Krishnamachari Y Seabold D Joshi V Schneider G and Salem AK. Intracelluar release of 17-β estradiol from cationic polyamidoamine dendrimer surface modified poly lactic-co-glycolic acid microparticles improves osteogenic differentiation of human mesenchymal stromal cells. Tissue Engineering, 2011.
Krishnamachari Y Geary SM Lemke CD and Salem AK. Nanoparticle delivery systems in cancer vaccines. Pharmaceutical Research, 2011.
Intra J and Salem AK. Rational design, fabrication, characterization and in vitro testing of biodegradable microparticles that generate targeted and sustained transgene expression in HepG2 liver cells. Journal of Drug Targeting, 2011.
Intra J and Salem AK. Fabrication, characterization and in vitro evaluation of poly lactic-co-glycolic acid microparticles loaded with polyamidoamine-plasmid DNA dendriplexes for applications in non-viral gene delivery. Journal of Pharmaceutical Sciences, 2010.
Petushkov A Ndiege N Salem AK and Larsen SC. Toxicity of Silica Nanomaterials: Zeolites, Mesoporous Silica, and Amorphous Silica Nanoparticles. Advances in Molecular Toxicology Vol 4. Elsevier 2010.
Salem AK and Behlke M. RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development. siRNA Delivery Vehicles, John Wiley & Sons Inc, 2010.
Petushkov A., J. Intra, J.B. Graham, S.C. Larsen, Salem AK. Effect of Crystal Size and Surface Functionalization on the Cytotoxicity of Silicalite-1 Nanoparticles. Chemical Research in Toxicology. 2009
Krishnamachari Y. and Salem AK. Innovative Strategies for Co-delivering Antigens and CpG Oligonucleotides. Advanced Drug Delivery Reviews. 61 (2009) 205-217
Salem AK and G.J. Weiner. CpG oligonucleotides as Immunotherapeutic Adjuvants: Innovative Applications and Delivery Strategies. Advanced Drug Delivery Reviews. 61 (2009) 193-194
Goforth R., Salem AK, X. Zhu, S. Miles, X.Q. Zhang, J. Lee, A.D. Sandler. Immune Stimulatory Antigen Loaded Particles Combined with Depletion of Regulatory T-cells Induce Potent Tumor Specific Immunity in a Mouse Model of Melanoma. Cancer Immunology, Immunotherapy 2009
Intra J., Salem AK. Characterization of the Transgene Expression Generated by Branched and Linear Polyethylenimine (PEI)-Plasmid DNA Nanoparticles In Vitro and After Intraperitoneal Injection In Vivo. Journal of Controlled Release. 2008
Pearce ME, Mai HQ, Lee N, Larsen SC, Salem AK. Silicalite nanoparticles that promote transgene expression. Nanotechnology 2008
Intra J, J.M Glasgow, H. Q. Mai, Salem AK. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Journal of Controlled Release 2008
Clapper JD, M.E. Pearce, C.A. Guymon, Salem AK. Biotinylated Biodegradable Nanotemplated Hydrogel Networks for Cell Interactive Applications. Biomacromolecules 2008
Krishnamachari Y., M.E. Pearce, Salem AK. Self-assembly of cell-microparticle hybrids. Advanced Materials. 2008
Zhang XQ, J. Intra, Salem AK. Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. Journal of Microencapsulation. 2008 1-13
Salem AK. Frontiers in Drug Design and Discovery. Volume 3. Journal of Medicinal Chemistry. 2008
Krishnamachari Y, Salem AK. Nano-Bio Polymers and Composites. Invited chapter in "Nano-and Biocomposites". Taylor & Francis/CRC Press. Edited by Lau and Hussain. 2008
Glasgow J, Salem AK. Stem Cells and Cancer. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008
Pearce ME, Salem AK. Stem Cell Research in Iowa. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008
Zhang XQ, J. Intra, Salem AK. Conjugation of polyamidoamine dendrimers on biodegradable microparticles for non-viral gene delivery. Bioconjugate Chemistry. 2007 Nov-Dec;18(6):2068-76
Abbas AO, M.D. Donovan, Salem AK. Formulating PLGA particles for plasmid DNA delivery. Journal of Pharmaceutical Sciences. 2007 DOI: 10.1002/jps.21215
Pearce ME, J.B. Melanko, Salem AK. Biomedical applications of multifunctional nanorods. Pharmaceutical Research. 2007 Dec; 24(12):2335-52
Zhang XQ, C.E. Dahle, G.J. Weiner and Salem AK. A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. Journal of Pharmaceutical Sciences. 2007 Dec;96(12):3283-92
Zhang XQ, C.E. Dahle, N.K. Baman, N. Rich, G.J. Weiner and Salem AK. Potent antigen-specific immune responses stimulated by co-delivery of CpG ODN and antigens in degradable microparticles. Journal of Immunotherapy, 30 (5): 469-478 July/August 2007
Salem AK, M. Behlke. siRNA delivery vehicles. Invited Chapter in the Book entitled "RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development". John Wiley & Sons Inc. 2007 Edited by Teresa N. Faria, Siew Peng Ho, and Oliver Steinbach.
Melanko JB, M.E. Pearce, Salem AK. Nanotubes/nanorods/nanofibers/fullerenes for nanoscale drug delivery. Invited Chapter in the Book entitled "Nanotechnology in Drug Delivery". Springer Science/American Association for Pharmaceutical Scientists (AAPS) 2007. Edited by Melgardt M. de Villiers, and Glen S. Kwon.
Salem AK, M.K. Salem, H.K. Salem, S. Tapya. New technologies and therapies for cancer. Invited review for the "Encyclopedia of Cancer and Society". Sage Publications 2007 . Edited by J. Geoffrey Golson and Graham A. Colditz.
Sinclair J, Salem AK. Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking. Biomaterials. 27 2090-2094 MAR 2006
Baman NK, G.B. Schneider, T.L. Terry, R. Zaharias, Salem AK. Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. International Journal of Nanomedicine, 1 (2): APR 2006
Salem AK. Frontiers in Drug Design and Discovery. Volume 2. Journal of Medicinal Chemistry. 2006 Dec 14;49(25):7555-6.
Salem AK, C.F. Hung, T.W. Kim, T.C. Wu, P.C. Searson, K.W. Leong. Multi-component nanorods for vaccination applications. Nanotechnology. 4 (16): 484-487 APR 2005
Hultgren A, M. Tanase, E.J. Felton, K. Bhadriraju, Salem AK, C.S. Chen, D.H. Reich. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. (21): 509-515 APR 2005
Salem AK and K.W. Leong. Polymer scaffolds for tissue engineering and gene delivery. Invited Chapter in the Book entitled "Scaffolding in Tissue Engineering". CRC Press 2005 Edited by: Jennifer Elisseeff and Peter X. Ma
Salem AK, M. Chen, J. Hayden, K.W. Leong, and P.C. Searson. Directed assembly of multi-segment Au/Pt/Au nanowires. Nanoletters. 4 (6): 1163-1165 JUN 2004
Salem AK, J. Chao, K.W. Leong, and P.C. Searson. Receptor mediated self-assembly of multi-component magnetic nanowires. Advanced Materials. 16 (3): 268+ FEB 3 2004
Salem AK, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671
Sakhalkar HS, M.K. Dalal, Salem AK, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proceedings of the National Academy of Sciences. 100 (26): 15895-15900 DEC 23 2003
Salem AK, F.R.A.J. Rose, R. Oreffo, X. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. Porous polymer and cell composites that self assemble in situ. Advanced Materials. 15 (3): 210-213 FEB 5 2003
Salem AK, R. Stevens, R.G. Pearson, M.C. Davies, S.J.B. Tendler and K.M. Shakesheff. Interactions of 3T3 fibroblasts and endothelial with defined pore features. Journal of Biomedical Materials Research. 61 (2) 212-217 Aug 2002
Salem AK, S.M. Cannizzaro, M.C. Davies, S.J.B. Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Synthesis and characterisation of a degradable biotinylated polylactic acid-polyethylene glycol copolymer. Biomacromolecules. Sum 2001, 2, 575-580