High Throughput Screening Facility

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University of Iowa Pharmaceuticals (UIP)

University of Iowa Pharmaceuticals (UIP) is an FDA-registered contract pharmaceutical manufacturing and analytical testing facility.  UIP services include clinical supply manufacturing, small scale commercial manufacturing, analytical method development and validation, routine quality control analysis, and stability studies.  UIP is capable of handling controlled substances and potent and cytotoxic compounds. UIP is produces most common pharmaceutical dosage forms, including sterile injectable solutions and lyophilized powders; topical semisolids and oral liquids; and tablets and capsules.  For more information, please visit http://uip.pharmacy.uiowa.edu.

Center for Biocatalysis and Bioprocessing (CBB)

CBB is a full-fledged microbial pilot plant facility with two Research and Process Development Laboratories at the University of Iowa.  CBB is fully compliant with FDA cGMP regulations.  Contract services ranging from cloning genes to strain selection are offered.   Fermentation processes can be scaled-up to 1000 L with matching protein purification capability.  CBB offers a range of analytical services including protein characterization, enzyme assays, endotoxin testing, and other common biological testing.  CBB has an excellent GMP facility for protein production for Phase I clinical trials at 300 L scale. For more information, please visit http://www.uiowa.edu/~biocat/.

Gene Vector Core of the Carver College of Medicine (GTVC)

The overall objective of the GTVC is to support investigators in the use of gene transfer technologies. The GTVC utilizes molecular biology techniques to engineer and develop viral vectors based on multiple vector systems necessary for gene transfer in research experiments or pre-clinical studies. GTVC staff and investigators work together allowing for cross fertilization of ideas, technical advancements, and innovations in vector design.  Services include consulting with the Principal Investigator to plan and develop transfer vectors to fit individual projects requirements; assisting investigators with troubleshooting existing projects; designing and developing of novel vectors; developing novel methods of virus production such as the RapAd™ System for adenovirus production and generation of RNAi expression vectors; construction, amplification, purification, concentration, and quality control on preparations of recombinant adenovirus, adeno-associated virus (AAV), moloney murine retrovirus, lentivirus, recombinant vaccinia virus, and baculovirus; and maintaining and distributing recombinant reporter viruses.  The GTVC services and products are provided at cost for investigators affiliated with educational institutions. For more information, please visit http://www.medicine.uiowa.edu/vectorcore/.

University of Iowa High Throughput Screening Facility (UIHTS)

The UIHTS is a high throughput screening platform that integrates robotics, detection systems, and chemical/biologics libraries. UIHTS enables scalable screening approaches, not only to foster hit and lead generation for drug discovery and development though screening of large chemical/biologics libraries; but also to facilitate molecular probe discovery for mechanism of action (MOA) studies of chemical biology through screening of focused intellectually-designed compound collections. As a University of Iowa core facility, UIHTS provides highly flexible screening services, project management, and assay/technology development for investigators across campus as well as off-campus. For more information please visit http://pharmacy.uiowa.edu/high-throughput-screening-facility.

National Advanced Driving Simulator (NADS)

NADS is the nation's premier driving simulation facility for conducting driving safety research on driver impairment and distraction.  The facility features the most comprehensive suite of simulators targeted to support research on testing the effects of pharmaceutical drugs on driving and studying human behavior in an experimentally controlled and safe environment.  The facility and staff have expertise and capabilities in the areas of experimental design, protocol development, IRB/regulatory submissions, participant recruitment, screening, data collection, data analysis, interpretation and reporting.  For more information, please visit www.nads-sc.uiowa.edu.

Institute for Clinical and Translational Science (ICTS)

ICTS supports and advances clinical and translational research at the University of Iowa. ICTS clinical research resources can support both internal and external investigators during all phases of the research process including biostatistics and study design consultation, budget preparation, contract negotiation, data management & secure storage, experienced study coordinators, FDA investigational drug & device applications, IRB & regulatory support, and access to the Clinical Research Unit and core labs.  We also offer one-year pilot grant awards of up to $50,000 to support innovative interdisciplinary studies fostering development and application of novel research methodologies for investigators and research personnel.  For more information, please visit http://www.icts.uiowa.edu/.

High Resolution Mass Spectrometry Facility (HRMSF)

HRMSF provides information pertaining to the molecular weight, elemental composition, and molecular structure of a compound.  This facility performs high resolution mass spectrometry (HR-MS) experiments or accurate mass measurements to confirm the elemental composition of new synthetic molecules and natural products.  Both gas and liquid chromatography interfaced with mass spectrometry (GC-MS and LC-MS) are utilized in the facility.  The HRMSF specializes in analysis of small molecules and is in a unique position to assist researchers interested in metabolomics.  The facility can confirm identification using both HR-MS data and tandem mass spectrometry data for structure elucidation and perform quantitative analysis of targeted metabolites.  The HRMSF staff is available for consultation with researchers to develop mass spectrometry strategies to resolve research problems.  Mass spectrometry services are also available to non-University of Iowa researchers.  For more information, please visit http://www.hrmsf.research.uiowa.edu/.

Central Microscopy Research Facility (CMRF)

The University of Iowa Central Microscopy Research Facility (CMRF) provides state-of-the-art light, confocal, Raman, scanning probe and electron microscopy methodology, instrumentation, instruction, technical assistance and development to all investigators.  CMRF staff can conduct research projects for investigators or train the investigators to use the available instrumentation on their own.  The facility is available 24/7 for those trained to use the instrumentation, with reservations made on a secure scheduling website.  For more information, please visit cmrf.research.uiowa.edu/.

Clinical Trials Statistical and Data Management Center (CTSDMC)

The CTSDMC is a Center within the Department of Biostatistics, School of Public Health at the University of Iowa.  The CTSDMC was created in 1989 to provide statistical and data management support for multicenter clinical trials.  The CTSDMC is a team of highly skilled and experienced project coordinators, database developers, data managers, biostatisticians, regulatory staff, and administrators committed to providing high quality infrastructure and support for multicenter clinical trials.  The principal mission of the CTSDMC is to provide comprehensive, premier-quality data management, statistical analysis, and administrative support to our clients through our commitment to accuracy, efficiency, and excellence in research.  We offer an experienced and professional research and support team with a proven record and well-developed strategies for supporting the development, implementation, and completion of multicenter clinical trials and the mechanistic studies associated with those trials. For more information, please visit www.ctsdmc.org/.