Introduction to Pharmaceutical Sciences: Drug Development
Introduction to the drug discovery, development, and approval pathways used in the United States with a specific focus on career pathways related to pharmaceutical development, including the natural and biomedical sciences, clinical, regulatory and legal affairs, sales and marketing, and business development.
Need A New Drug?
Introduction to drug discovery, development, and approval process in the United States with a focus on preclinical and clinical development activities and the role of the FDA and other regulatory bodies in the approval and oversight of available drug products.
Medicines That Changed the World
Herbal remedies and ancient traditional medicines have led to the discovery of life-saving drug therapies; as science has evolved, how the discovery of other important medicines have come about through advances in chemistry and biology and now through advances in computer science and informatics; students learn about the discovery history of some of the most important drug therapies of the 20th and 21st centuries and how those discoveries are leading to even more important, life-saving treatments.
Introduction to Biocatalysis in Drug Discovery
Applications of biological catalysis in pharmaceutical development and production; potential of biological catalysis to address future challenges in drug discovery.
Basic Principles of Toxicology
Basic principles and mechanisms of toxicology as it relates to drugs and environmental agents.
Specific toxicants and toxicity not related to organ systems including carcinogenesis and oxidative stress; clinical toxicology and antidotes. PHAR:4503 Organ and Organ Toxicity How toxicants, such as drugs, interact with organ systems and organisms.
Principles of Drug Discovery
Focus on understanding drug targets as receptors, receptor theory, drug discovery, and new drug approval processes; areas of novel drug target identification, pharmacological characterization of new drugs, G protein coupled receptors as targets, and analysis of drug-receptor interactions.
High Throughput Screening in Drug Discovery
Introduction to high throughput screening (HTS) and its application in pharmaceutical and biomedical sciences; description and use of HTS in identification of biologically-active small molecules for use as probes, tool compounds, and drug leads; detection systems, robotic liquid handling instruments, and compound libraries; case studies of HTS approaches used in drug discovery.
Principles and Approaches to Medicinal Chemistry
Modern techniques used in drug discovery; important drug classes, their chemical mechanism of action.
Small Molecule Drug Design
Modern chemical methods for construction of carbon-carbon bonds commonly used in synthesis of natural products; strategic disconnections for the syntheses of these molecules.
Chemical and Biophysical Properties of Drugs
Introduction to design of drug molecules based on an understanding of drug-like properties including chemical reactivity and structural optimization; minimization of potentially toxic biotransformations; optimization of absorption; screening methods for selection and classification of optimized molecules.