General pharmacology (e.g., administration, distribution, and elimination of drugs, dose response curves, adverse effects, placebos, homeopathy); pharmacotherapy of selected human diseases, pathophysiologic aspects of the disease, how different classes of drugs modify pathophysiologic effects to restore health or reduce disease's impact; focus on mechanisms of drug actions in humans; adverse effects, pharmacokinetic considerations, drug interactions; how to write prescriptions.
Principles of drug action, toxicity; sedatives, stimulants, hallucinogens, narcotics, over-the-counter agents, antibiotics, oral contraceptives. Offered spring semesters.
Introduction to principles of pharmacology, pharmacologic actions of drugs. Offered spring semesters.
Introduction to the drug discovery, development, and approval pathways used in the United States with a specific focus on career pathways related to pharmaceutical development, including the natural and biomedical sciences, clinical, regulatory and legal affairs, sales and marketing, and business development.
Introduction to drug discovery, development, and approval process in the United States with a focus on preclinical and clinical development activities and the role of the FDA and other regulatory bodies in the approval and oversight of available drug products.
Herbal remedies and ancient traditional medicines have led to the discovery of life-saving drug therapies; as science has evolved, how the discovery of other important medicines have come about through advances in chemistry and biology and now through advances in computer science and informatics; students learn about the discovery history of some of the most important drug therapies of the 20th and 21st centuries and how those discoveries are leading to even more important, life-saving treatments.
An introduction to drug absorption, distribution and elimination processes controlling overall drug exposure in humans. Basic quantitative measurements will be presented and used to demonstrate the influence of drug properties and physiologic action on drug disposition.
Basic principles and mechanisms of toxicology as it relates to drugs and environmental agents.
Specific toxicants and toxicity not related to organ systems including carcinogenesis and oxidative stress; clinical toxicology and antidotes.
How toxicants, such as drugs, interact with organ systems and organisms.
Focus on understanding drug targets as receptors, receptor theory, drug discovery, and new drug approval processes; areas of novel drug target identification, pharmacological characterization of new drugs, G protein coupled receptors as targets, and analysis of drug-receptor interactions.
Principles of drug metabolism based on current knowledge of involved enzymes.
Introduction to design of drug molecules based on an understanding of drug-like properties including chemical reactivity and structural optimization; minimization of potentially toxic biotransformations; optimization of absorption; screening methods for selection and classification of optimized molecules.
Application of pharmacokinetics and pharmacodynamics principles in pharmaceutical research.