Lewis L Stevens

Lewis L Stevens

  • Assistant Professor, Department of Pharmaceutical Sciences and Experimental Therapeutics / Division of Pharmaceutics and Translational Therapeutics

Office

S219 PHAR

Phone

(319) 335-8823

Research Narrative

Dr. Stevens’ current research interests focus on extending our knowledge of intermolecular interactions for insight into structure-function relationships in small-molecule and bio-inspired pharmaceuticals. The problem of drug delivery and bioavailability presents itself uniquely for each new pharmaceutical application and remains a fundamental question. A clear understanding of material property expression, as it relates to pharmaceuticals, is rooted in a diversity of coupled and competing mechanisms requiring a commensurably diverse scientific approach for transformative insight. My research program, with its cornerstone being the advancement of Brillouin scattering (an analog to Raman scattering) into a multi-dimensional, analytical tool, emphasizes physical chemistry and the interpretation of acoustic, vibrational spectra for expanding our mechanistic understanding of drug-delivery phenomena: protein aggregation, packing polymorphism and stress-induced phase nucleation/transformations. Predictive control of these phenomena extended to current and next-generation pharmaceuticals represents the ultimate goal of my research. Members of my group will gain a multi-disciplinary experience in protein dynamics (folding, aggregation), biopharmaceuticals, mechano- and physical chemistry of solids, laser-light scattering and high-pressure physics with the emphasis being a capacity to draw substantive connections across disciplines for application to pharmaceutics.

Curriculum vitae

Education
2005 PhD (Chemistry) University of Nebraska - Lincoln
1999 BA (Chemistry) Hastings University

Professional Experience
2012-Present, Assistant Professor, Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA
2008-2012, Manager of Technology and Development, AgSource Laboratories, Lincoln, NE
2006-2008, Postdoctoral Fellow, Los Alamos National Laboratory, Los Alamos, NM
1999-2005, Research Assistant, Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE

Honors and Awards
Sigma Xi National Honor Society, 2005
College of Arts and Sciences Outstanding Graduate Teaching Assistant, 2003
Department of Chemistry Outstanding Graduate Teaching Assistant, 2003
Department of Chemistry Chair’s Fellowship, 1999-2001
Walter Scott Scholarship, 1995-1999
Lutheran Brotherhood Scholarship, 1995-1999

Recent Publications
Benjamin AS, Ahart M, Gramsch SA, Stevens LL, Orler BE, Dattelbaum DM  and Hemley RJ, Acoustic properties of Kel-F 800 copolymer up to 85 GPa, Journal of Chemical Physics, 137(1), 014514, 2012.

Stevens LL, Dattelbaum DM, Ahart M, and Hemley RJ, High-pressure elastic properties of a flourinated copolymer: Poly(chlorotrifluoroethylene-co-vinylidene flouride) (Kel-F 800), Journal of Applied Physics, 112(2), 023523, 2012.

Velisavljevic N, Chesnut GN, Stevens LL, and Dattelbaum DM, Effects of interstitial impurities on the high pressure martensitic a to w structural transformation and grain growth in zirconium, Journal of Physics: Condensed Matter, 23, 125402, 2011.

Stevens LL, Migliori A and Hooks DE, A comparative analysis of the mechanical properties of pentaerythritol tetranitrate (PETN), Journal of Applied Physics, 138, 053512, 2010.

Bedrov D, Borodin O, Smith GD, Sewell TD, Dattelbaum DM and Stevens LL, A molecular dynamics simulation study of crystalline 1,3,5-triamino-2,4,6-trinitrobenzene as a function of pressure and temperature, Journal of Chemical Physics, 131(22), 224703, 2009.

Stevens LL, Velisavljevic N, Hooks DE and Dattelbaum DM, High-pressure phase stability of 2,4,6-trinitrotoluene (TNT) to 26.5 GPa, Applied Physics Letters, 93, 081912, 2008.

Stevens LL, Velisavljevic N, Hooks DE and Dattelbaum DM, Hydrostatic compression curve for triamino-trinitrobenzene (TATB) determined to 13.0 GPa with powder X-ray diffraction, Propellants, Explosives and Pyrotechnics, 33(4), 286, 2008.

Dattelbaum DM, Stevens LL, Orler BE, Ahart M and Hemley RJ, Brillouin-scattering determination of the acoustic properties of polymers at high pressure, in Proceedings of the 15th American Physical Society Topical Conference on Shock Compression of Condensed Matter, 2007.

Stevens LL, Orler BE, Dattelbaum DM, Ahart M and Hemley RJ, A Brillouin-scattering determination of the acoustic properties and their pressure dependence for three polymeric elastomers, Journal of Chemical Physics, 127, 104906, 2007.

Haycraft JJ, Stevens LL and Eckhardt CJ, Single-crystal, polarized, Raman-scattering study of the molecular and lattice vibrations for the energetic material cyclotrimethylene trinitramine (RDX), Journal of Applied Physics, 100, 053508, 2006.

Haycraft JJ, Stevens LL and Eckhardt CJ, The elastic constants and related properties of the energetic material RDX determined by Brillouin scattering, Journal of Chemical Physics, 124, 024712, 2006.

Stevens LL, Haycraft JJ and Eckhardt CJ, Single-crystal, polarized, Raman-scattering study of the molecular and lattice vibrations for the energetic material beta-HMX, Crystal Growth and Design, 5(6), 2060, 2005.

Stevens LL and Eckhardt CJ, The elastic constants and related properties of beta-HMX determined by Brillouin scattering, Journal of Chemical Physics, 122, 174701, 2005.

Dattelbaum DM and Stevens LL, Equations of state of Non-crystalline Materials: High Explosive Binders and related Polymers, in Energetic Materials at Static High Pressures, ed. G. Piermarini and S. Peiris.