Peter Veng-Pedersen

Peter Veng-Pedersen

  • Emeritus Professor, Department of Pharmaceutical Sciences and Experimental Therapeutics / Division of Pharmaceutics and Translational Therapeutics

Office

208-1 PHAR

Phone

(319) 335-8792

Research Narrative

Dr. Veng-Pedersen's main research interests include the pharmacokinetics and pharmacodynamics (PK/PD) of erythropoietin in pre-mature, very low birth weight babies, the PK/PD of the insulin-glucose system in diabetic and pre-diabetic subjects, and the kinetic assessment and optimization of drug delivery.

Curriculum vitae

Education
1970 BS (Pharmacy), University of Copenhagen
1975 MS (Pharmacy), University of Sydney
1977 PhD (Pharmacy), University of Sydney

Professional Experience
1991-present, Professor, Division of Pharmaceutics, College of Pharmacy, The University of Iowa
1984-1991, Associate Professor, Division of Pharmaceutics, College of Pharmacy, The University of Iowa
1980-1984, Associate Professor, Department of Pharmaceutics, School of Pharmacy and Pharmacal Sciences, Purdue University
1977-1980, Assistant Professor, Department of Pharmacy and Medicinal Chemistry, School of Pharmacy, University of California San Francisco

Research Interests
Dr. Veng-Pedersen's main research interests include the pharmacokinetics and pharmacodynamics (PK/PD) of erythropoietin in pre-mature, very low birth weight babies, the PK/PD of the insulin-glucose system in diabetic and pre-diabetic subjects, and the kinetic assessment and optimization of drug delivery.

Recent Research Articles (out of more than 146 research article publications)
Rosebraugh MR, Widness JA, Nalbant D, Veng-Pedersen P. A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. Transfusion. 53(6):1353-60, 2013.

Mock DM, Matthews NI, Zhu S, Strauss RG, Schmidt RL, Zimmerman MB, Nalbant D, Freise KJ, Saleh M, Veng-Pedersen P, Widness JA. Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [14C]cyanate: validation of a model to study human physiology and disease. Transfusion. 52(5):963-73, 2012.

Saleh MI, Widness JA, Veng-Pedersen P. Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep. Biopharm Drug Dispos. 32(3):131-9, 2011.

Rosebraugh M, Widness JA, Veng-Pedersen P. Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy. Drug Metab Dispos. 39(7):1214-20, 2011.

Mock DM, Matthews NI, Zhu S, Burmeister LF, Zimmerman MB, Strauss RG, Schmidt RL, Nalbant D, Freise KJ, Veng-Pedersen P, Widness JA. Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin. Transfusion. 50(12):2553-64, 2010.

Widness JA, Schmidt RL, Hohl RJ, Goldman FD, Al-Huniti NH, Freise KJ, Veng-Pedersen P. Change in erythropoietin pharmacokinetics following hematopoietic transplantation. Clin Pharmacol Ther. 81(6):873-9, 2007.

Mock DM Matthews NI and Zhu S, et al. Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin. Transfusion Vol 50 Iss 12 pp 2553-2564, 2010.

Osei-Bimpong A Saleh M and Sola-Visner M, et al. Correction for Effect of Cold Storage on Immature Platelet Fraction. Journal of Clinical Laboratory Analysis Vol 24 Iss 6 pp 431-433, 2010.

Xie LY Hoffman RP and Veng-Pedersen P. Population analysis of ethnicity and first-phase insulin release. Diabetes Research and Clinical Practice Vol 89 Iss 3 pp 243-249, 2010.

Lanyi X Hoffman RP and Veng-Pedersen P. Population analysis of ethnicity and first-phase insulin release. Diabetes Research and Clinical Practice Vol 89 Iss 3 pp 243-249, 2010.

Nalbant D Saleh M and Goldman FD, et al. Evidence of Receptor-Mediated Elimination of Erythropoietin by Analysis of Erythropoietin Receptor mRNA Expression in Bone Marrow and Erythropoietin Clearance During Anemia. Journal of Pharmacology and Experimental Therapeutics Vol 333 Iss 2 pp 528-532, 2010.

Kania-Korwel I El-Komy MHME and Veng-Pedersen P et al.Clearance of Polychlorinated Biphenyl Atropisomers is Enantioselective in Female C57Bl/6 Mice. Environmental Science & Technology Vol 44 Iss 8 pp 2828-2835, 2010.

Freise KJ Widness JA and Veng-Pedersen P. Erythropoietic Response to Endogenous Erythropoietin in Premature Very Low Birth Weight Infants. Journal of Pharmacology and Experimental Therapeutics Vol 332 Iss 1 pp 229-237, 2010.

Lin CW and Veng-Pedersen P. Analysis of PK/PD risk factors for development of type 2 diabetes in high risk population using Bayesian analysis of glucose-insulin kinetics. Journal of Pharmacokinetics and Pharmacodynamics Vol 36 Iss 5 pp 421-441, 2009.

Lin CW and Veng-Pedersen P. Analysis of PK/PD risk factors for development of type 2 diabetes in high risk population using Bayesian analysis of glucose-insulin kinetics. Journal of Pharmacokinetics and Pharmacodynamics Vol 36 Iss 5 pp 421-441, 2009.

Freise KJ Schmidt RL and Gingerich EL, et al. The effect of anticoagulant, storage temperature and dilution on cord blood hematology parameters over time. International Journal of Laboratory Hematology Vol 31 Iss 5 pp 496-504, 2009.

Xie LY Hoffman RP and Veng-Pedersen P. Noncompartmental Pharmacokinetics Analysis of Glucose-Stimulated Insulin Response in African-American and Caucasian Youths. Biopharmaceutics & Drug Disposition Vol 30 Iss 3 pp 117-125, 2009.

Neelakantan S Widness JA and Schmidt RL, et al.Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. Pediatrics International Vol 51 Iss 1 pp 25-32, 2009.

D.M. Mock, N.I. Matthews, S Zhu, et al. Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin. Transfusion 50(12): 2553-2564, 2010.

A Osei-Bimpong, M Saley, M Sola-Visner, et al. Correction for Effect of Cold Storage on Immature Platelet Fraction. Journal of Clinical Laboratory Analysis 24 (6): 431-433, 2010.

L.Y. Xie, R.P. Hoffman, P. Veng-Petersen. Population analysis of ethnicity and first-phase insulin release 89 (3): 243-249, 2010.

Lanyi Xie, P. Robert, P. Veng-Petersen. Diabetes Research and Clinical Practice, 89 (3): 243-249, September 2010.

D. Nalbant, M. Saleh, F.D. Goldman, et al. Evidence of Receptor-Medicated Elimination of Erythropoietin by Analysis of Erythropoietin Receptor mRNA Expression in Bone Marrow and Erythropoietin Clearance During Anemia. Journal of Pharmacology and Experimental Therapeutics, 333 (2): 528-532, 2010.

I Kania-Korwel, MHME El-Komy, P. Veng-Petersen. Clearance of Polychlorinated Biphenyl Atropisomers is Enantioselective in Female C57BI/6 Mice. Environmental Science & Technology, 44 (8): 2828-2835, 2010.

K.J. Freise, J.A. Widness, P. Veng-Pedersen. Erythropoietic Response to Endogenous Erythropoietin in Premature Very Low Birth Weight Infants. Jounral of Pharmacology and Experimental Therapeutics, 332 (1): 229-237, 2010.

K.J. Freise, J.A. Widness, P. Veng-Pedersen. Erythropoietic Response to Endogenous Erythropoietin in Premature Very Low Birth Weight Infants. Journal of Pharmacology and Experimental Therapeutics 332 (1): 229-237, January 2010.

C.W. Lin, P. Veng-Pedersen. Analysis of PK/PD risk factors for development of type 2 diabetes in high risk population using Bayesian analysis of glucose-insulin kinetics. Journal of Pharmacokinetics and Pharmacodynamics, 36 (5): 421-441, 2009.

Lin, Chih-Wei; Veng-Pedersen, Peter. Analysis of PK/PD risk factors for development of type 2 diabetes in high risk population using Bayesian analysis of glucose-insulin kinetics. Journal of Pharmacokinetics and Pharmacodynamics, 36 (5): 421-441, October 2009.

Freise, KJ; Schmidt, RL; Gingerich, EL, et al. The effect of anticoagulant, storage temperature and dilution on cord blood hematology parameters over time. International Journal of Laboratory Hematology, 31 (5): 496-504, 2009.

Xie, LY; Hoffman, RP; Veng-Pedersen, P. Noncompartmental Pharmacokinetics Analysis of Glucose-Stimulated Insulin Response in African-American and Caucasian Youths. Biopharmaceutics & Drug Disposition, 30(3): 117-125, 2009.

Neelakantan, S; Widness, JA; Schmidt, RL, et al. Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. Pediatrics International, 51(1):25-32, 2009.

K. J. Freise, J. A. Widness, R. L. Schmidt, and P. Veng-Pedersen. Modeling time variant distributions of cellular lifespans: increases in circulating reticulocyte lifespans following double phlebotomies in sheep. Journal of Pharmacokinetics and Pharmacodynamics 35:285-323, (2008).

S. Neelakantan,J. Widness, R. Schmidt, P. Veng-Pedersen. Erythropoietin Pharmacodynamic Analysis Suggests Higher Doses in Treating Neonatal Anemia. Pediatrics International June, 2008.

P. Veng-Pedersen, K.J. Freise, R.L. Schmidt, J.A. Widness, Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin. Journal of Pharmacy and Pharmacology, 60 , 1321-1334, 2008.

K. J. Freise, R. L. Schmidt, J. A. Widness, and P. Veng-Pedersen. Pharmacodynamic modeling of the effect of changes in the environment on cellular lifespan and cellular responsePharmacodynamic modeling of the effect of changes in the environment on cellular lifespan and cellular response. Journal of Pharmacokinetics and Pharmacodynamics. 35:527-552, 2008.

Widness JA, Veng-Pedersen P, Freise KJ, Cress GC, Gingerich EL. Keeping blood in the baby: strategies for reducing blood sampling. Neonatology, 94:228-229, 2008.

Freise KJ, Schmidt RL, Gingerich EL, Veng-Pedersen P and Widness JA. The effect of anticoagulant, storage temperature, and dilution on cord blood hematology indices over time. International Journal of Laboratory Hematology. Int J Lab Hematol. 2008 Apr (2008).

Friese KJ, Widness JA, Schmidt RL, and Veng-Pedersen P. Pharmacokinetic/Pharmacodynamic Analysis of Time-Variant Cellular Disposition: Reticulocyte Disposition Changes in Phlebotomized Sheep. Journal of Pharmacokinetics and Pharmacodynamics. 34, 4, 519-547 (2007).

Friese KJ, Widness JA, Segar JL, Schmidt RL, and Veng-Pedersen P. Increased erythropoietin elimination in fetal sheep following chronic phlebotomy. Pharmaceutical Research. 24, 9 , 1653-1659, (2007).

Gupta N, Al-Huniti NH, Veng-Pedersen P. Individualized Pharmacokinetic Risk Assessment For Development Of Diabetes In High Risk Population. Diabetes Res Clin Pract. 1,93-101(2006).

Widness JA, Schmidt RL, Hohl RJ, Goldman FD, Al-Huniti NH, Freise KJ, Veng-Pedersen P. Change In Erythropoietin Pharmacokinetics Following Hematopoietic Stem Cell Transplantation. Clinical Pharmacology and Therapeutics. 77, 2, 16-26 (2006).

Durairaj L, Neelakantan S, Launspach J, Watt JL, Allaman MM, Kearney WR, Veng-Pedersen P, and Zabner J. Bronchoscopic assessment of airway retention time of aerosolized xylitol. Respir Res. 7(1): 27. (2006).

Warwood TL, Ohls RK, Lambert DK, Jones C, Scoffield SH, Gupta N, Veng-Pedersen P, and Christensen RD. Intravenous administration of darbepoetin to NICU patients. Journal of Perinatology 26, 296–300 (2006).

Warwood TL, Ohls RK, Lambert DK, Leve EA, Veng-Pedersen P, and Christensen RD. Urinary Excretion Of Darbepoetin After Intravenous And Subcutaneous Administration To Preterm Neonates. Journal of Perinatology 26, 636–639 (2006).

Gupta N, Hoffman RP, Veng-Pedersen P. Pharmacokinetic/pharmacodynamic insulin-glucose analysis for differentiation of beta-cell function: an 18 month follow-up study in pre-pubertal lean and obese children. Biopharmaceutics & Drug Disposition27, 6 , 257 – 265 (2006).

Neelakantan S, Widness JA, Schmidt RL, and Veng-Pedersen P. A “Bottom-Up” Approach For Endo-Pk/Pd Analysis. Biopharmaceutics and Drug Disposition. 27,313-327 (2006).