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Guohua An, MD, PhD

Associate Professor

Introduction

After receiving her MD from Taishan Medical College and MS in Clinical Pharmacology from Fudan University, Dr. An joined Ruijin Hospital for 2 years as a clinical pharmacist and research scientist. Then she pursued a further study and got her PhD degree in Pharmaceutical Sciences from SUNY at Buffalo. After graduation, she joined the R&D group of Abbott (currently known as AbbVie), where she gained extensive hands on experience in clinical drug development, PK/PD modeling and simulation. Prior to joining University of Iowa, Dr. An has worked at University of Florida as an Assistant Professor for one and half years. Her current research interests include building mechanism-based pharmacokinetic and pharmacodynamic modeling of small molecules and large molecules; model-informed drug development (such as antiparasitic drugs and novel HSD-1 inhibitors) and model-informed clinical care (such as antibiotics); population pharmacokinetic modeling of drugs in special populations (such as infants, critically ill patients, and surgical patients); as well as quantitative systems pharmacology (QSP).

Dr. An is an editor of Journal of Pharmaceutical Sciences, and she serves as an editorial board member of Journal of Clinical Pharmacology, The AAPS Journal, and Journal of Pharmacokinetics and Pharmacodynamics. Dr. An has been in the pharmaceutical sciences field for 18 years and has published 96 peer-reviewed articles (as of Dec 2024) in various top journals in the field. She wrote a single author pharmacokinetic textbook, entitled “Essentials in Clinical Pharmacokinetics: Concepts, Dose Optimization, and Biologics”, which was released in May 2024 and is available at Amazon (https://www.amazon.com/Essentials-Clinical-Pharmacokinetics-Optimization-Biologics/dp/1964623006).

Current Positions

  • Associate Professor of Pharmaceutical Sciences and Experimental Therapeutics

Education

  • MS, Fudan University, Shanghai, China
  • PhD, SUNY, University at Buffalo, Buffalo, New York, United States

Research Interests

  • Mechanistic PKPD modeling and simulation
  • Population PK in Special Populations
  • Model-Informed Drug Development
  • Quantitative Systems Pharmacology

Selected Publications

  • Reeder JA, Creech B, Nation RL, Gu K, Nalbant D, Fishbane N, Wu N, Jimenez-Truque N, Fissell W, Rolsma S, Patel P, Watanabe A, Kirkpatrick CMJ, Landersdorfer CB, Winokur P, and An G *. Utilizing Opportunistic Clinical Study and Population-Based Pharmacometric Models to Identify Rational Empiric Dosing Regimens for Piperacillin-Tazobactam in Critically Ill Patients. J of Clinical Pharmacology 2024 Dec 3. doi: 10.1002/jcph.6161. Online ahead of print. PMID: 39628093
  • Rolsma SL, Sokolow A, Patel P, Sokolow K, Jimenez-Truque N, Fissell WH, Ryan V, Kirkpatrick CM, Nation RL, Gu K, Teresi M, Fishbane N, Kontos M, An G, Winokur P, Landersdorfer CB, Creech CB. Population Pharmcokinetics Modeling of Cefepime, Meropenem, and Piperacillin-tazobactam in Patients with Cystic Fibrosis.   J Infect Dis. 2024 [Online ahead of print]. PMID: 39344185.
  • Yuan X, An G*. A Target-mediated Drug Disposition Model to Explain the Nonlinear Pharmacokinetics of the 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor BI-187004 in Healthy Subjects.  Journal of Clinical Pharmacology 2024 Apr 23. doi: 10.1002/jcph.2438. Online ahead of print.  PMID: 38652112  
  • Wu N, and An G*.  A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. J Pharm Sci 2024 Jan; 113(1): 278-289. doi: 10.1016/j.xphs.2023.09.006. PMID: 37716531   
  • An G*. Pharmacokinetics and pharmacodynamics of GalNAc-conjugated siRNAs. J Clin Pharmacol. 2024 Jan; 64(1):45-57. doi: 10.1002/jcph.2337. PMID: 37589246
  • Xu M, Sun D, and An G *. Exploring the Impact of Pharmacological Target-Mediated Low Plasma Exposure in Lead Compound Selection in Drug Discovery – a Modeling Approach.  The AAPS Journal 2024 Oct 28;26(6):112. doi: 10.1208/s12248-024-00979-7.   PMID: 39467882
  • An G*, Creech B, Wu N, Nation RL, Gu K, Nalbant D, Jimenez-Truque N, Fissell W, Rolsma S, Patel P, Watanabe A, Fishbane N, Kirkpatrick CMJ, Landersdorfer CB, and Winokur P,*. Population Pharmacokinetics and Target Attainment Analysis to Identify a Rational Empiric Dosing Strategy for Cefepime in Critically Ill Patients. J Antimicrob Chemother 2023 Jun 1;78(6):1460-1470. doi: 10.1093/jac/dkad106.      PMID: 37071586
  • Reeder, J. A., O'Sullivan, C. T., Xu, M., Wu, N., Ince, D., Rogers, W. K. & An, G. (2023). Model-Informed Clinical Practice - Determining an Appropriate Ampicillin-Sulbactam Redosing Regimen in Surgical Patients by Utilizing Population Pharmacokinetics and Target Attainment Analysis. Antimicrobial agents and chemotherapy e0124822. DOI: 10.1128/aac.01248-22. PMID: 36920230.
  • Wu N, Katz D, and An G*. Population Target-Mediated Pharmacokinetics/Pharmacodynamics Modeling to Quantitatively Evaluate SPI-62 Exposure and Its Inhibition on Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) In Healthy Adults. Clinical Pharmacokinetics 2023 Sep; 62(9):1275-1288. doi: 10.1007/s40262-023-01278-8. PMID: 37452998
  • Xu M, and An G*. A pharmacometric model to characterize a new type of target-mediated drug disposition (TMDD) – nonlinear pharmacokinetics of small-molecule PF-07059013 mediated by its high-capacity pharmacological target hemoglobin with positive cooperative binding. The AAPS Journal 2023 Apr 13;25(3):41. doi: 10.1208/s12248-023-00808-3.   PMID: 37055588