Pharmaceutical Sciences and Experimental Therapeutics faculty are committed to impactful, diverse and innovative programs of scholarship focused on drug discovery and drug delivery. We strive to maintain a creative and supportive environment to train the next generation of biomedical/pharmaceutical scientists and healthcare professionals.
--Jonathan A Doorn, Department Chair
Medicinal and natural products chemistry is a discipline that encompasses discovery, design, synthesis, and testing of new medicinal agents. Research at Iowa includes a strong synthetic medicinal chemistry component including the development of new synthetic methodologies to construct anti-infective, anti-cancer and anti-viral agents. Faculty members are also focused on drug metabolism and carcinogenesis, chemical toxicology, and neurochemistry. Research is be conducted in gene delivery system development, and the identification of novel targets for anticancer agents and the treatment of central nervous system disorders as well as the discovery of novel pre-therapeutic lead molecules through the use of High Throughput Screening. Additionally, small molecule drug discovery is achieve through structure-based drug design (SBDD) and computer-aided drug discovery (CADD), with a strong emphasis on enzyme drug targets.
A second area of focus concentrates on pharmaceutics and translational therapeutics. Faculty members are investigating the development of novel drug delivery systems for both small and large molecules, including delivery of genetic material. Another intense research activity includes the field of tissue engineering, developing and integrating minimally invasive strategies to deliver scaffolds in vivo. Research areas also include physical pharmacy, dosage form development and performance, and industrial/manufacturing pharmacy, as well as the pharmacokinetics and pharmacodynamics of drugs and biological molecules. Several faculty members are focused on research in drug delivery and targeting, pharmacogenomics and individualized therapy. Applied and fundamental research, aimed at improving and re-engineering the pharmaceutical product, process design, and development, is yet another focus area.