1. Home
  2. Person Directory

Jonathan Doorn, PhD

John L. & Carol E. Lach Endowed Chair, Department Chair & Professor

Current Positions

  • Professor of Pharmaceutical Sciences and Experimental Therapeutics

Education

  • BS, Calvin College, Grand Rapids, Michigan
  • Ph.D., Toxicology, The University of Michigan, Ann Arbor, Michigan, United States
  • Postdoctoral Fellow in Pharmaceutical Sciences/Pharmacology, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado

Selected Awards & Honors

  • John Doull Award in Toxicology, Central States Society of Toxicology
  • Regular Member, NAL Study Section, NIH
  • Co-Chair, Mechanisms of Neurotoxicity, Neurodegeneration and Neurodevelopmental Dysfunction Induced by Metals and Pesticides, Society of Toxicology, Nashville, Tennessee, United States
  • Session Chair and Co-Organizer, 56th Congress of the European Society of Toxicology, Cophenhagen, Denmark
  • College of Pharmacy Collegiate Teacher of the Year, University of Iowa, College of Pharmacy
  • CIC DEO Fellows Seminar, Big Ten Academic Alliance, Big Ten Center, Rosemont, Illinois, United States

Professional Memberships

  • Interdisciplinary Graduate Program Neuroscience
  • Interdisciplinary Graduate Program Human Toxicology

Research Interests

  • Dopamine Metabolism
  • Mechanistic Toxicology
  • Parkinson's Disease
  • Drug Discovery

Selected Publications

  • Paranjape, N., Strack, S., Lehmler, H.J., and Doorn, J.A. (2024) Astrocyte mitochondria are a sensitive target of PCB52 and its human-relevant metabolites. ACS Chem Neurosci. 15, 2729-2740. PMCID: PMC1131113
  • Bartman, A.E., Raeisi, M., Peiris, C.D., Jacobsen, J.E., Martin, D.B.C., and Doorn, J.A. (2024) A novel analog of the natural product fraxinellone protects against endogenous and exogenous neurotoxicants. ACS Chem Neurosci. 15, 2612-2622. PMCID: PMC11258694
  • Currim, F., Tanwar, R., Brown-Leung, J.M., Paranjape, N., Liu, J., Sanders, L.H., Doorn, J.A., and Cannon, J.R. (2024) Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology. NeuroToxicol. 103, 266-287. PMCID: PMC11288778
  • Li, Z., Ekanayake, A.B., bartman, A.E., Doorn, J.A., Tivanski, A.V., Pigge, F.C. (2024) Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum complexes. Dalton Trans. 53, 9001-9010.
  • Paranjape, N.E., Dean, L.E., Martinez, A., Tjalkens, R.B., Lehmler, H.J., and Doorn, J.A. (2023) Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity. Chem. Res. Toxicol. 36, 971-981. PMCID: PMC10283044
  • Martinez, P.A., Martinez, V.E., Rani, S., Murrell, M., Javors, M., Gelfond, J., Doorn, J.A., Fernandez, E., and Strong, R. (2023). Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease. Brain Behav. e3150.
  • Bullert, A., Li, X., Chunyun, Z., Lee, K., Pulliam, C.F., Cagle, B.S., Doorn, J.A., Klingelhutz, A.J., Robertson, l.W., Lehmler, H.J. (2023). Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ. Toxicol. Pharmacol. 102: 10425
  • Nelson, M. M., Efird, J. T., Kew, K. A., Katunga, L. A., Monroe, T. B., Doorn, J. A., Beatty, C. N., Shi, Q., Akhter, S. A., Alwair, H., Robidoux, J. & Anderson, E. J. (2021). Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients. ANTIOXIDANTS & REDOX SIGNALING 35 (4) 235-251. DOI: 10.1089/ars.2020.8122.
  • Cagle, B.S., Sturgeon, M.L., O’Brien, J.B., Wilkinson, J.C., Cornell, R.A., Roman, D.L., and Doorn, J.A (2021). Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism. Toxicol. In Vitro. 76, 105210. PMCID: PMC8479135.