Michael Duffel, PhD
Professor Emeritus
Current Positions
- Professor Emeritus, Pharmaceutical Sciences and Experimental Therapeutics
Research Interests
- Sulfation and sulfotransferases in drug metabolism, toxicology, chemical carcinogenesis, and endocrine disruption
Selected Publications
- Duffel, M.W. (2024). Cytosolic sulfotransferases in endocrine disruption. Essays in Biochemistry. 68, 541-553. DOI: 10.1042/EBC20230101
- Duffel, M.W. and Lehmler, H.-J. (2024). Complex roles for sulfation in the toxicities of polychlorinated biphenyls. Critical Reviews in Toxicology. 54: 92-122, DOI: 10.1080/10408444.2024.2311270
- Duffel, M.W. (2023). Sulfotransferases. In Reference Module in Biomedical Sciences. DOI: 10.1016/B978-0-323-95488-4.00005-X
- Zhang, D., Saktrakulkla, P., Marek, R.F., Lehmler, H.-J., Wang, K., Thorne, P.S., Hornbuckle, K.C., Duffel, M.W. (2022). PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities. Environmental Science and Technology. 56: 6537–6547. DOI: 10.1021/acs.est.2c00223. PMCID: PMC9118556.
- Duffel, M.W., Tuttle, K., Lehmler, H.J., and Robertson, L.W. (2021). Human Hepatic Microsomal Sulfatase Catalyzes the Hydrolysis of Polychlorinated Biphenyl Sulfates: A Potential Mechanism for Retention of Hydroxylated PCBs. Environmental Toxicology and Pharmacology. 88:103757. DOI: 10.1016/j.etap.2021.103757. PMCID: PMC8595862.
- Zhang, D., Saktrakulkla, P., Tuttle, K., Marek, R.F., Lehmler, H.J., Wang, K., Hornbuckle, K.C., and Duffel, M.W. (2021). Detection and Quantification of Polychlorinated Biphenyl Sulfates in Human Serum. Environmental Science and Technology. 55:2473-2481. doi: 10.1021/acs.est.0c06983. PMCID: PMC7924310.