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David Roman, PhD

Associate Dean for Research and Graduate Education & Professor

Current Positions

  • Professor of Pharmaceutical Sciences and Experimental Therapeutics
  • Associate Dean for Research and Graduate Education & Professor, Office of the Dean

Selected Awards & Honors

  • College of Pharmacy P1 Teacher of the Year Award, University of Iowa College of Pharmacy, Iowa City, Iowa, United States
  • University of Iowa Innovator Award, University of Iowa, Iowa City, Iowa, United States

Research Interests

  • Pharmacological Sciences Training Program (NIH T32)

Selected Publications

  • Dwyer, T. S., O'Brien, J. B., Ptak, C. P., LaVigne, J. E., Flaherty, D. P., Watts, V. J. & Roman, D. L. (2022). Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype. Frontiers in pharmacology 13 977742. DOI: 10.3389/fphar.2022.977742. PMID: 36147328. PMCID: PMC9486168.
  • Alexander, S. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A., Ahlers-Dannen, K. E., Alqinyah, M., Arumugam, T. V., Bodle, C., Dagner, J. B., Chakravarti, B., Choudhuri, S. P., Druey, K. M., Fisher, R. A., Gerber, K. J., Hepler, J. R., Hooks, S. B., Kantheti, H. S., Karaj, B., Layeghi-Ghalehsoukhteh, S., Lee, J. K., Luo, Z., Martemyanov, K., Mascarenhas, L. D., McNabb, H., Montañez-Miranda, C., Ogujiofor, O., Phan, H., Roman, D. L., Shaw, V., Sjogren, B., Sobey, C., Spicer, M. M., Squires, K. E., Sutton, L., Wendimu, M., Wilkie, T., Xie, K., Zhang, Q. & Zolghadri, Y. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. British journal of pharmacology 178 Suppl 1 (Suppl 1) S1-S26. DOI: 10.1111/bph.15537. PMID: 34529830. PMCID: PMC9513948.
  • Cagle, B. S., Sturgeon, M. L., O'Brien, J. B., Wilkinson, J. C., Cornell, R. A., Roman, D. L. & Doorn, J. A. (2021). Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism. Toxicology in vitro : an international journal published in association with BIBRA 76 105210. DOI: 10.1016/j.tiv.2021.105210. PMID: 34252731. PMCID: PMC8419135.
  • O'Brien, J. B. & Roman, D. L. (2021). Novel treatments for chronic pain: moving beyond opioids. Translational research : the journal of laboratory and clinical medicine 234 1-19. DOI: 10.1016/j.trsl.2021.03.008. PMID: 33727192.
  • Hayes, M. P., O'Brien, J. B., Crawford, R. A., Fowler, C. A., Yu, L., Doorn, J. A. & Roman, D. L. (2021). Fragment-Based Nuclear Magnetic Resonance Screen against a Regulator of G Protein Signaling Identifies a Binding "Hot Spot". Chembiochem : a European journal of chemical biology 22 (9) 1609-1620. DOI: 10.1002/cbic.202000740. PMID: 33480159. PMCID: PMC8546901.
  • O'Brien, J. B., Wilkinson, J. C. & Roman, D. L. (2019). Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials. The Journal of biological chemistry 294 (49) 18571-18585. DOI: 10.1074/jbc.REV119.007060. PMID: 31636120. PMCID: PMC6901330.
  • Sieng, M., Hayes, M. P., O'Brien, J. B., Andrew Fowler, C., Houtman, J. C., Roman, D. L. & Lyon, A. M. (2019). High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. The Journal of biological chemistry 294 (20) 8148-8160. DOI: 10.1074/jbc.RA118.006059. PMID: 30940727. PMCID: PMC6527179.
  • Bodle, C. R., Schamp, J. H., O'Brien, J. B., Hayes, M. P., Wu, M., Doorn, J. A. & Roman, D. L. (2018). Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. SLAS discovery : advancing life sciences R & D 23 (4) 363-374. DOI: 10.1177/2472555217752301. PMID: 29351497. PMCID: PMC6342279.
  • Hayes, M. P., Soto-Velasquez, M., Fowler, C. A., Watts, V. J. & Roman, D. L. (2018). Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin. ACS chemical neuroscience 9 (2) 346-357. DOI: 10.1021/acschemneuro.7b00349. PMID: 28968502. PMCID: PMC6362833.
  • Hayes, M. P., Bodle, C. R. & Roman, D. L. (2018). Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family. Molecular pharmacology 93 (1) 25-35. DOI: 10.1124/mol.117.109843. PMID: 29051318. PMCID: PMC5708088.