1. Home
  2. Person Directory

Ethan Anderson, PhD

Professor

Introduction

Work in Dr. Anderson’s lab is directed at understanding mitochondrial oxidative metabolism of nutrients and catecholamines in the heart and other organ systems (e.g., liver, immune), and how these metabolic pathways become dysfunctional during disease and contribute to cardiometabolic complications of diabetes and sepsis. Pre-clinical testing and development of novel small molecules that target mitochondria or cellular metabolism is an integral part of our research. Experimental models used in the lab range from in vitro biochemistry to cell culture & genetically modified mice. Integration of broad ‘omic analysis, particularly metabolomics (profiling and stable isotope tracer) is frequently incorporated in our models. Whenever possible, our experimental findings are validated using independent cohorts of human tissue specimens and cell culture.

Current Positions

  • Professor of Pharmaceutical Sciences and Experimental Therapeutics
  • Drug Discovery & Experimental Therapeutics, Division Head

Education

  • BS in Genetics, University of Minnesota
  • PhD in Molecular Physiology, Yale University
  • Postdoctoral Fellow in Molecular Cardiology and Metabolism, East Carolina University

Selected Publications

  • Monroe, T. & Anderson, E. J. (2021). A Catecholaldehyde Metabolite of Norepinephrine Induces Myofibroblast Activation and Toxicity via the Receptor for Advanced Glycation Endproducts: Mitigating Role of l-Carnosine. Chemical Research in Toxicology 34 (10) 2194–2201. DOI: 10.1021/acs.chemrestox.1c00262.
  • Mattox, T. A., Psaltis, C., Weihbrecht, K., Robidoux, J., Kilburg-Basnyat, B., Murphy, M. P., Gowdy, K. M. & Anderson, E. J. (2021). Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. Journal of the American Heart Association 10 (14). DOI: 10.1161/JAHA.120.019877. PMID: 34219469.
  • Crawford, R. A., Gilardoni, E., Monroe, T. B., Regazzoni, L., Anderson, E. J. & Doorn, J. A. (2021). Characterization of Catecholaldehyde Adducts with Carnosine and L-Cysteine Reveals Their Potential as Biomarkers of Catecholaminergic Stress. CHEMICAL RESEARCH IN TOXICOLOGY 34 (10) 2184-2193. DOI: 10.1021/acs.chemrestox.1c00153.
  • Nelson, M. M., Efird, J. T., Kew, K. A., Katunga, L. A., Monroe, T. B., Doorn, J. A., Beatty, C. N., Shi, Q., Akhter, S. A., Alwair, H., Robidoux, J. & Anderson, E. J. (2020). Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients. Antioxid Redox Signal 35 (4) 235-251. DOI: 10.1089/ars.2020.8122.
  • Nelson, M. M., Builta, Z. J., Monroe, T. B., Doorn, J. A. & Anderson, E. J. (2018). Biochemical characterization of the catecholaldehyde reactivity of l-carnosine and its therapeutic potential in human myocardium. Amino acids 51 (1) 97-102. DOI: 10.1007/s00726-018-2647-y. PMID: 30191330.
  • Stein, C. S., Jadiya, P., Zhang, X., McLendon, J. M., Abouassaly, G. M., Witmer, N. H., Anderson, E. J., Elrod, J. W. & Boudreau, R. L. (2018). Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Cell reports 23 (13) 3710-3720.e8. DOI: 10.1016/j.celrep.2018.06.002. PMID: 29949756. PMCID: PMC6091870.
  • Anderson, E. J., Vistoli, G., Katunga, L. A., Funai, K., Regazzoni, L., Monroe, T. B., Gilardoni, E., Cannizzaro, L., Colzani, M., De Maddis, Danilo, Rossoni, G., Canevotti, R., Gagliardi, S., Carini, M. & Aldini, G. (2018). A Carnosine Analog Mitigates Metabolic Disorders of Obesity by Reducing Carbonyl Stress. The Journal of Clinical Investigation 128 (12) 5280-5293. DOI: 10.1172/JCI94307. PMID: 30226473. PMCID: PMC6264636.
  • Anderson, E. J., Efird, J. T., Kiser, A. C., Crane, P. B., O’Neal, W. T., Ferguson, T. B., Alwair, H., Carter, K., Williams, J. M. & Gehi, A. K. (2017). Plasma Catecholamine Levels on the Morning of Surgery Predict Post-Operative Atrial Fibrillation. JACC: Clinical Electrophysiology 3 (12) 1456–1465.
  • Katunga, L. A., Gudimella, P., Efird, J. T., Abernathy, S., Mattox, T. A., Beatty, C., Darden, T. M., Thayne, K. A., Alwair, H., Kypson, A. P., Virag, J. A. & Anderson, E. J. (2015). Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy (vol 4, pg 493, 2015). (Vols. 4). (10), pp. 753-753. MOLECULAR METABOLISM. DOI: 10.1016/j.molmet.2015.06.005.
  • Katunga, L. A., Gudimella, P., Efird, J. T., Abernathy, S., Mattox, T. A., Beatty, C., Darden, T. M., Thayne, K. A., Alwair, H., Kypson, A. P., Virag, J. A. & Anderson, E. J. (2015). Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Molecular Metabolism 4 (10) 753-753. DOI: 10.1016/j.molmet.2015.06.005.