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Jared M. McLendon, PhD

Assistant Professor

Current Positions

  • Assistant Professor of Pharmaceutical Sciences and Experimental Therapeutics
  • Member of the Abboud Cardiovascular Research Center
  • Member of the Iowa Neuroscience Institute

Education

  • PhD, Basic Medical Sciences, University of South Alabama College of Medicine, Mobile, Alabama
  • Postdoctoral Research Fellow, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa
  • BS, Biomedical Science, College of Allied Health, University of South Alabama, Mobile Alabama

Professional Memberships

  • American Heart Association (AHA)
  • American Physiological Society (APS)
  • International Society to Advance Alzheimer’s Research and Treatment (ISTAART)
  • International Society for Heart Research, North American Section (ISHR)

Selected Publications

  • Witmer, N. H., McLendon, J. M., Stein, C. S., Yoon, J.-Y., Berezhnaya, E., Elrod, J. W., London, B. L., & Boudreau, R. L. (2024). Upstream alternative polyadenylation in SCN5A produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration. bioRxiv, 2024.2008.2009.607406. https://doi.org/10.1101/2024.08.09.607406. In Review at Circulation Research.
  • Ismaeel, A., Peck, B. D., Montgomery, M. M., Burke, B. I., Goh, J., Kang, G., Franco, A. B., Xia, Q., Goljanek-Whysall, K., McDonagh, B., McLendon, J. M., Koopmans, P. J., Jacko, D., Schaaf, K., Bloch, W., Gehlert, S., Wen, Y., Murach, K. A., Peterson, C. A.,…McCarthy, J. J. (2024). microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism. bioRxiv, 2024.2008.2009.607377. https://doi.org/10.1101/2024.08.09.607377. In Review at Molecular Cell.
  • McLendon, J. M., Zhang, X., Stein, C. S., Baehr, L. M., Bodine, S. C., & Boudreau, R. L. (2024). A Specialized Centrosome-Proteasome Axis Mediates Proteostasis and Influences Cardiac Stress through Txlnb. bioRxiv, 2024.2002.2012.580020. https://doi.org/10.1101/2024.02.12.580020. In Review at Journal Molecular Cellular Cardiology.
  • Berdaweel, I. A., Monroe, T. B., Alowaisi, A. A., Mahoney, J. C., Liang, I.-C., Berns, K. A., Gao, D., McLendon, J. M., & Anderson, E. J. (2024). Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity. Frontiers in Pharmacology, 14. doi:10.3389/fphar.2023.1275388
  • Zhang, X., McLendon, J. M., Peck, B. D., Chen, B., Song, L.-S., & Boudreau, R. L. (2023). Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix. Molecular Therapy - Nucleic Acids, 34, 102081. doi:https://doi.org/10.1016/j.omtn.2023.102081
  • Stein, C. S., McLendon, J. M., Witmer, N. H., & Boudreau, R. L. (2022). Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease. Mol Ther Nucleic Acids, 28, 1-15. doi:10.1016/j.omtn.2022.02.007
  • McLendon, J. M., Zhang, X., Matasic, D. S., Kumar, M., Koval, O. M., Grumbach, I. M., Sadayappan, S., London, B., & Boudreau, R. L. (2022). Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. J Am Heart Assoc, 11(13), e025687. doi:10.1161/jaha.122.025687
  • Ramelli, S. C., Comer, B. S., McLendon, J. M., Sandy, L. L., Ferretti, A. P., Barrington, R., Sparks, J., Matar, M., Fewell, J., & Gerthoffer, W. T. (2020). Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma. Mol Ther Nucleic Acids, 19, 1000-1014. doi:10.1016/j.omtn.2019.12.033
  • Matasic, D. S., Yoon, J. Y., McLendon, J. M., Mehdi, H., Schmidt, M. S., Greiner, A. M., Quinones, P., Morgan, G. M., Boudreau, R. L., Irani, K., Brenner, C., & London, B. (2020). Modulation of the cardiac sodium channel NaV1.5 peak and late currents by NAD(+) precursors. J Mol Cell Cardiol, 141, 70-81. doi:10.1016/j.yjmcc.2020.01.013
  • Oshima, K., Crockett, E. S., Joshi, S. R., McLendon, J. M., Matsumoto, Y., McMurtry, I. F., Abe, K., & Oka, M. (2019). Aneurysm-type plexiform lesions form in supernumerary arteries in pulmonary arterial hypertension: potential therapeutic implications. Am J Physiol Lung Cell Mol Physiol, 317(6), L805-L815. doi:10.1152/ajplung.00121.2019

Selected Grants & Contracts

  • Role of Smooth Muscle Sorbs2 in Vascular Pathobiology; American Heart Association; Jared M. McLendon (PI)
  • Molecular Significance of Sorbs2 in Alzheimer’s Disease; Alzheimer’s Association; Jared M. McLendon (PI)