Nicole K. Brogden, PharmD, PhD
Introduction
Dr. Brogden is a clinical pharmacist and pharmaceutical scientist with a translational research program centered around topical and transdermal drug delivery. There is a strong emphasis on physical enhancement techniques such as microneedles and applied heat. The Brogden lab has a very clinical focus, with much of the work involving human subjects and development of drug delivery approaches to improve human health. Specific research areas include:
Effects of skin physiology on micropore closure after microneedle insertion, with an emphasis on skin of color
Formulation effects on local vs systemic drug delivery through microneedle-treated skin
Use of microneedles for acute vs chronic drug delivery needs
Optimizing formulations for skin with impaired barrier function (ex: wound sites)
Dr. Brogden has received research funding from the FDA, National Institutes of Health, American Association of Colleges of Pharmacy, and other small foundations and cosmetic companies.
Current Positions
- Associate Professor of Pharmaceutical Sciences and Experimental Therapeutics
- Associate Professor of Dermatology
Selected Awards & Honors
- Co-chair, Gordon Research Conference: Barrier Function of Mammalian Skin
- Fellow, Yale University Innovation to Impact course
- Genesis Award, University of Iowa College of Pharmacy
- Nominee, Early Career Scholar of the Year, University of Iowa
- NIH Early Career Reviewer Program, NIH Center for Scientfic Review
- Scholarship recipient, Fundamentals of Pain Management: An Interdisciplinary Primer course, American Pain Society
- Montagna Symposium on the Biology of Skin/Society for INvestigative Dermatology Eugene M. Farber Travel Award for Young Investigators
- Women of Innovation Award, Research Innovation an Leadership category, Technology Association of Iowa and Principal Financial Group
Professional Memberships
- Rho Chi Honor Society
- Phi Lambda Sigma
Selected Publications
- Chougule, M. B. & Brogden, N. K. (2022). Introducing the Molecular Pharmaceutics Special Issue on "Interdisciplinary Integration of Biomaterials for Drug and Gene Therapy". (Vols. 19). (12), pp. 4391. Molecular pharmaceutics. DOI: 10.1021/acs.molpharmaceut.2c00971. PMID: 36465013.
- Ortiz-de León, C., Hartwick, C. J., Stuedemann, C. A., Brogden, N. K. & MacGillivray, L. R. (2022). Mechanochemistry Facilitates a Single-Crystal X-ray Structure Determination of Free Base Naloxone Anhydrate. Crystal growth & design 22 (11) 6622-6626. DOI: 10.1021/acs.cgd.2c00831. PMID: 36345388. PMCID: PMC9634803.
- Russo, J., Fiegel, J. & Brogden, N. K. (2022). Effect of Salt Form on Gelation and Drug Delivery Properties of Diclofenac-Loaded Poloxamer Gels for Delivery to Impaired Skin. Pharmaceutical research 39 (10) 2515-2527. DOI: 10.1007/s11095-022-03356-1. PMID: 36002613. PMCID: PMC9578569.
- Tobin, K. V., Fiegel, J. & Brogden, N. K. (2021). Thermosensitive Gels Used to Improve Microneedle-Assisted Transdermal Delivery of Naltrexone. Polymers 13 (6). DOI: 10.3390/polym13060933. PMID: 33803552. PMCID: PMC8002892.
- Ogunjimi, A. T., Lawson, C., Carr, J., Patel, K. K., Ferguson, N. & Brogden, N. K. (2021). Micropore Closure Rates following Microneedle Application at Various Anatomical Sites in Healthy Human Subjects. Skin pharmacology and physiology 34 (4) 214-228. DOI: 10.1159/000515454. PMID: 33910205. PMCID: PMC8259462.
- Russo, J., Fiegel, J. & Brogden, N. K. (2020). Rheological and Drug Delivery Characteristics of Poloxamer-Based Diclofenac Sodium Formulations for Chronic Wound Site Analgesia. Pharmaceutics 12 (12). DOI: 10.3390/pharmaceutics12121214. PMID: 33333773. PMCID: PMC7765230.
- Ogunjimi, A. T., Carr, J., Lawson, C., Ferguson, N. & Brogden, N. K. (2020). Micropore closure time is longer following microneedle application to skin of color. Scientific reports 10 (1) 18963. DOI: 10.1038/s41598-020-75246-8. PMID: 33144596. PMCID: PMC7609754.
- Ogunjimi, A. T., Fiegel, J. & Brogden, N. K. (2020). Design and Characterization of Spray-Dried Chitosan-Naltrexone Microspheres for Microneedle-Assisted Transdermal Delivery. Pharmaceutics 12 (6). DOI: 10.3390/pharmaceutics12060496. PMID: 32485999. PMCID: PMC7355536.
- Swaminathan, S. K., Strasinger, C., Kelchen, M., Carr, J., Ye, W., Wokovich, A., Ghosh, P., Rajagopal, S., Ueda, K., Fisher, J., Kandimalla, K. K. & Brogden, N. K. (2020). Determination of Rate and Extent of Scopolamine Release from Transderm Scōp® Transdermal Drug Delivery Systems in Healthy Human Adults. AAPS PharmSciTech 21 (3) 117. DOI: 10.1208/s12249-020-01658-4. PMID: 32300962.
- Smith, R., Russo, J., Fiegel, J. & Brogden, N. (2020). Antibiotic delivery strategies to treat skin infections when innate antimicrobial defense fails. Antibiotics 9 (2). PMID: 32024064.