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Reza Nejadnik, PhD

Associate Professor

Introduction

Reza Nejadnik's research is focused on protein pharmaceuticals, their formulation and characterization, and interaction of biologics with interfaces. Delivery, handling and manufacturing processes of protein therapeutics are also among his topics of interest. Reza Received his PhD from the University of Groningen in the Netherlands back in 2009. Following a few years of research in the area of proteins, nano and biomaterials at The University of Texas, Northwestern University and Radboud University Nijmegen, Reza joined the Leiden Academic Center for Drug Research in order to co-lead a European public-private partnership project (COMPACT) that addressed the current challenges with formulation and delivery of macromolecules. In the 4-year period of the COMPACT project, Reza’s research focused on characterization and understanding of protein aggregation in complex formulations as well as protein-material interactions. Reza then joined the Global Biologic Drug Product Development team of Sanofi and headed a formulation and process development laboratory in the Company’s R&D hub in Frankfurt, Germany. He developed early formulations and drug product manufacturing processes for several molecules in various modalities including antibodies and nanobodies. Reza is currently a faculty member of the Department of Pharmaceutical Sciences and Experimental Therapeutics.

Current Positions

  • Associate Professor of Pharmaceutical Sciences and Experimental Therapeutics

Education

  • Materials Science and Engineering, Isfahan University of Technology, Isfahan, Iran
  • Biomedical Engineering (Biomaterials), Amirkabir University of Technology, Tehran, Iran
  • Biomedical Engineering (Biomaterials), University of Groningen, Groningen, Netherlands

Research Interests

  • Formulation and delivery of protein therapeutics (monoclonal antibodies and other novel modalities)
  • Protein adsorption and protein material interactions
  • Devices and handling/manufacturing processes for protein pharmaceuticals
  • Biophysical characterization of proteins

Selected Publications

  • Refaat, H., Ahmad, A., Kamel, E., Gurvich, V.J., Rathore, A.S., Suryanarayanan, R., Nejadnik, R. (2025). Challenges with Effective Removal of Surfactants from Monoclonal Antibody Formulations. International Journal of Pharmaceutics. 670:125146. DOI: 10.1016/j.ijpharm.2024.125146
  • Ahmad, A., Refaat, H., Bhattacharya, S., Gurvich, V.J., Rathore, A.S., Nejadnik, R., Suryanarayanan, R. (2025). Effect of Formulation Composition on Trastuzumab Stability. International Journal of Pharmaceutics. 671:125275.
  • Rahman, Y., Hejmady, S., Nejadnik, R. (2024). Prediction of Self-Association and Solution Behavior of Monoclonal Antibodies Using the QCM-D Metric of Loosely Interacting Layer. Molecular Pharmaceutics. 22. DOI: 10.1021/acs.molpharmaceut.4c00656
  • Sarin, D., Krishna, K., Nejadnik, M.R., Suryanarayanan, R., Rathore, A.S. (2024). Impact of Excipient Extraction and Buffer Exchange on Recombinant Monoclonal Antibody Stability. Molecular Pharmaceutics. 21:1872-1883.
  • Fast, J., Christian, T., Crul M., Jiskoot, W., Nejadnik, M.R., Medina, A., Radwick, A., Sreedhara, A., Tole, H. (2024). Use of Closed System Transfer Devices (CSTDs) with Protein-Based Therapeutic Drugs - A Non-Solution for a Non-Problem? Journal of Pharmaceutical Sciences. 113:298-305.
  • Geersing, T.H., Dogan, D., Nejadnik, M.R., Romeijn, S., Knibbe, C.A.J., Crul, M. (2024). Aggregate Formation and Antibody Stability in Infusion Bags: The Impact of Manual and Robotic Compounding of Monoclonal Antibodies. Journal of Pharmaceutical Sciences. 113:1029-1037.
  • Medina Morales, A., Sreedhara, A., Buecheler, J., Brosig, S., Chou, D., Christian, T., Das, T., de Jong, I., Fast, J., Jagannathan, B., Moussa, E.M., Nejadnik, M.R., Prajapati, I., Radwick, A., Rahman, Y., Singh, S. (2023). End-to-end approach to surfactant selection, risk mitigation, and control strategies for protein-based therapeutics. The AAPS Journal. 25:6.
  • Leone, M., Priester, M.I., Romeijn, S., Nejadnik, M.R., Mönkäre, J., O'Mahony, C., Jiskoot, W., Kersten, G., Bouwstra, J.A. (2019). Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment. European Journal of Pharmaceutics and Biopharmaceutics. 134:49-59.
  • Leone, M., van Oorschot, B.H., Nejadnik, M.R., Bocchino, A., Rosato, M., Kersten, G., O’Mahony, C., Bouwstra, J.A., van der Maaden, K. (2018). Universal applicator for digitally-controlled pressing force and impact velocity insertion of microneedles into skin. Pharmaceutics. 10:211.
  • Mönkäre, J., Pontier, M., van Kampen, E.E.M., Du, G., Leone, M., Romeijn, S., Nejadnik, M.R., O'Mahony, C., Slütter, B., Jiskoot, W., Bouwstra, J.A. (2018). Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery. European Journal of Pharmaceutics and Biopharmaceutics. 129:111-121.