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Reza Nejadnik, PhD

Associate Professor

Introduction

Reza Nejadnik's research is focused on protein pharmaceuticals, their formulation and characterization, and interaction of biologics with interfaces. Delivery, handling and manufacturing processes of protein therapeutics are also among his topics of interest. Reza Received his PhD from the University of Groningen in the Netherlands back in 2009. Following a few years of research in the area of proteins, nano and biomaterials at The University of Texas, Northwestern University and Radboud University Nijmegen, Reza joined the Leiden Academic Center for Drug Research in order to co-lead a European public-private partnership project (COMPACT) that addressed the current challenges with formulation and delivery of macromolecules. In the 4-year period of the COMPACT project, Reza’s research focused on characterization and understanding of protein aggregation in complex formulations as well as protein-material interactions. Reza then joined the Global Biologic Drug Product Development team of Sanofi and headed a formulation and process development laboratory in the Company’s R&D hub in Frankfurt, Germany. He developed early formulations and drug product manufacturing processes for several molecules in various modalities including antibodies and nanobodies. Reza is currently a faculty member of the Department of Pharmaceutical Sciences and Experimental Therapeutics.

Current Positions

  • Associate Professor of Pharmaceutical Sciences and Experimental Therapeutics

Education

  • Materials Science and Engineering, Isfahan University of Technology, Isfahan, Iran
  • Biomedical Engineering (Biomaterials), Amirkabir University of Technology, Tehran, Iran
  • Biomedical Engineering (Biomaterials), University of Groningen, Groningen, Netherlands

Research Interests

  • Formulation and delivery of protein therapeutics (monoclonal antibodies and other novel modalities)
  • Protein adsorption and protein material interactions
  • Devices and handling/manufacturing processes for protein pharmaceuticals
  • Biophysical characterization of proteins

Selected Publications

  • Yusra Rahman, Siddhanth Hejmady, and Reza Nejadnik (2024). Prediction of Self-Association and Solution Behavior of Monoclonal Antibodies Using the QCM-D Metric of Loosely Interacting Layer https://doi.org/10.1021/acs.molpharmaceut.4c00656
  • Hesham Refaat, Aziz Ahmad, Eman Kamel, Vadim J. Gurvich, Anurag S. Rathore, Raj Suryanarayanan, Reza Nejadnik (2025). Challenges with effective removal of surfactants from monoclonal antibody formulations. International Journal of Pharmaceutics https://doi.org/10.1016/j.ijpharm.2024.125146
  • Nejadnik, M. R., Randolph, T. W., Volkin, D. B., Schöneich, C., Carpenter, J. F., Crommelin, D. J. & Jiskoot, W. (2018). Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. Journal of Pharmaceutical Sciences 107 (8) 2013-2019. DOI: 10.1016/j.xphs.2018.04.005.
  • El Bialy, I., Jiskoot, W. & Reza Nejadnik (2017). Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration. (Vols. 34). (6), pp. 1152-1170. Pharmaceutical Research. DOI: 10.1007/s11095-017-2147-x.
  • Sediq, Waasdorp, Nejadnik, van Beers, Meulenaar, Verrijk & Jiskoot (2017). Determination of the Porosity of PLGA Microparticles by Tracking Their Sedimentation Velocity Using a Flow Imaging Microscope (FlowCAM). Pharmaceutical Research 34 (5) 1104-1114. DOI: 10.1007/s11095-017-2120-8.
  • Sediq, A. S., Van Duijvenvoorde, Jiskoot, W. & Nejadnik, M. R. (2016). No Touching! Abrasion of Adsorbed Protein Is the Root Cause of Subvisible Particle Formation during Stirring. Journal of Pharmaceutical Sciences 105 (2) 519-529. DOI: 10.1016/j.xphs.2015.10.003.
  • Mönkäre, J., Reza Nejadnik, Baccouche, K., Romeijn, S., Jiskoot, W. & Bouwstra, J. A. (2015). IgG-loaded hyaluronan-based dissolving microneedles for intradermal protein delivery. Journal of Controlled Release 218 53-62. DOI: 10.1016/j.jconrel.2015.10.002.
  • Nejadnik, M. R. & Jiskoot, W. (2015). Measurement of the average mass of proteins adsorbed to a nanoparticle by using a suspended microchannel resonator. Journal of Pharmaceutical Sciences 104 (2) 698-704. DOI: 10.1002/jps.24206.
  • Nejadnik, M. R., Deepak, F. L. & Garcia, C. D. (2011). Adsorption of Glucose Oxidase to 3-D Scaffolds of Carbon Nanotubes: Analytical Applications. Electroanalysis 23 (6) 1462-1469. DOI: 10.1002/elan.201000758.
  • End-to-end approach to surfactant selection, risk mitigation, and control strategies for protein-based therapeutics. The APPS Journal 25 1-15.